Magnetically Triggered Release From Giant Unilamellar Vesicles: Visualization By Means Of Confocal Microscopy

Silvia Nappini, Tamer Al Kayal, Debora Berti, Bengt Nordèn, Piero Baglioni

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Magnetically triggered release from magnetic giant unilamellar vesicles (GUVs) loaded with Alexa fluorescent dye was studied by means of confocal laser scanning microscopy (CLSM) under a low-frequency alternating magnetic field (LF-AMF). Core/shell cobalt ferrite nanoparticles coated with rhodamine B isothiocyanate (MP@SiO 2(RITC)) were prepared and adsorbed on the GUV membrane. The MP@SiO 2(RITC) location and distribution on giant lipid vesicles were determined by 3D-CLSM projections, and their effect on the release properties and GUV permeability under a LF-AMF was investigated by CLSM time-resolved experiments. We show that the mechanism of release of the fluorescent dye during the LF-AMF exposure is induced by magnetic nanoparticle energy and mechanical vibration, which promote the perturbation of the GUV membrane without its collapse. © 2011 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalThe Journal of Physical Chemistry Letters
Issue number7
StatePublished - Mar 10 2011
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Financial support from CSGI, MIUR-PRIN (2008-20087K9A2J), and FIRB (RBPR05JH2P ITALNANONET) is acknowledged. B.N. acknowledges a King Abdullah University of Science and Technology Award making this project possible. Dr. Tore Eriksson is acknowledged for building the alternating magnetic field generator.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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