Magnetic MOF for AO7 removal and targeted delivery

Xue Qing Zhan; Xiao Yan Yu; Fang Chang Tsai; Ning Ma; Huan Li Liu; Yu Han; Lei Xie; Tao Jiang; Dean Shi; Yan Xiong

doi:10.3390/cryst8060250

Magnetic MOF for AO7 removal and targeted delivery

Xue Qing Zhan, Xiao Yan Yu, Fang Chang Tsai^*, Ning Ma, Huan Li Liu, Yu Han, Lei Xie, Tao Jiang, Dean Shi, Yan Xiong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Owing to their high surface area and porosity, metal-organic frameworks (MOFs) have been gradually employed for a myriad of applications ranging from sensing, pollutant adsorption, and drug delivery to environmental remediation and catalysis. Magnetic nanoparticles-metal-organic frameworks (MMOFs) hybrid materials can facilitate facile removal of MOFs from solutions. In this report, we report the synthesis of Fe₃O₄@UiO-66 by encapsulation and simulated the drug loading and release by studying the adsorption and release of AO7. Thus, we loaded these MMOFs with AO7 and found that they were able to trigger and control its release by simply applying an external magnetic field. The magnetic field heats the magnets in the MOF, which causes the load to burst from the framework.

Original language	English (US)
Article number	250
Journal	Crystals
Volume	8
Issue number	6
DOIs	https://doi.org/10.3390/cryst8060250
State	Published - Jun 15 2018

Bibliographical note

Funding Information:
capacity (140 mg/g) comparable to the conventional UiO-66 (140 mg/g) and the release rate of the dye under the action of methanol are also considerable. By comparing the properties and structure of AO7 with similar drugs, we think some drugs such as Aspirin and Iressa can also be adsorbed by down, whichensuresthat the drugis better absorbed by the body.Some promising applicationsin Fe3O4@UiO-66. Because of the effect of pH on drug release, the rate of release is somewhat slowed industrialsustainability,medicalprocesses,andenvironment-relatedareasarealsodiscussed. down, which ensures that the drug is better absorbed by the body. Some promising applications in indusSturpiapllesmusetnatainryaMbialitteyri,amls:eTdhiecafolllporwoicnegsasreesa,vaanildabelenovnilrionenamtwenwtw-r.emladtpeid.coamr/exaxsx/as1r,eVaildseoo:dFies3cOu4@ssUeiOd-.66 dispersioninthepresenceofamagnetfield. Supplementary Materials: The following are available online at http://www.mdpi.com/2073-4352/8/6/250/s1, AuthorContributions:Themanuscriptwaswrittenthroughcontributionsofallauthors.Allauthorshavegiven Video: Fe3O4@UiO-66 dispersion in the presence of a magnet field. approvaltothefinalversionofthemanuscript. Author Contributions: The manuscript was written through contributions of all authors. All authors have given approvalAckntoowtheledfinalgemeversionnt: Thisofsttheudymanuscript.has been supported by the National High Technology Research and Development Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science FoundationofChinaNo.2014CFB552;HubeiCollaborativeInnovationCenterforAdvancedOrganicChemical Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science Foundation of China MaterialsofChinaNo.000-01647909. No. 2014CFB552; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials of China No. 00C0o-n0f1l6ic4t7s9o0f9I.nterest:Theauthorsdeclarenoconflictofinterest.

Funding Information:
This study has been supported by the National High Technology Research and Development Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science Foundation of China No. 2014CFB552; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials of China No. 000-01647909.

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

AO7
Magnetic MOFs
Targeted delivery
Triggered release

ASJC Scopus subject areas

Chemical Engineering(all)
Materials Science(all)
Condensed Matter Physics
Inorganic Chemistry

Access to Document

10.3390/cryst8060250

Cite this

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title = "Magnetic MOF for AO7 removal and targeted delivery",

abstract = "Owing to their high surface area and porosity, metal-organic frameworks (MOFs) have been gradually employed for a myriad of applications ranging from sensing, pollutant adsorption, and drug delivery to environmental remediation and catalysis. Magnetic nanoparticles-metal-organic frameworks (MMOFs) hybrid materials can facilitate facile removal of MOFs from solutions. In this report, we report the synthesis of Fe3O4@UiO-66 by encapsulation and simulated the drug loading and release by studying the adsorption and release of AO7. Thus, we loaded these MMOFs with AO7 and found that they were able to trigger and control its release by simply applying an external magnetic field. The magnetic field heats the magnets in the MOF, which causes the load to burst from the framework.",

keywords = "AO7, Magnetic MOFs, Targeted delivery, Triggered release",

author = "Zhan, {Xue Qing} and Yu, {Xiao Yan} and Tsai, {Fang Chang} and Ning Ma and Liu, {Huan Li} and Yu Han and Lei Xie and Tao Jiang and Dean Shi and Yan Xiong",

note = "Funding Information: capacity (140 mg/g) comparable to the conventional UiO-66 (140 mg/g) and the release rate of the dye under the action of methanol are also considerable. By comparing the properties and structure of AO7 with similar drugs, we think some drugs such as Aspirin and Iressa can also be adsorbed by down, whichensuresthat the drugis better absorbed by the body.Some promising applicationsin Fe3O4@UiO-66. Because of the effect of pH on drug release, the rate of release is somewhat slowed industrialsustainability,medicalprocesses,andenvironment-relatedareasarealsodiscussed. down, which ensures that the drug is better absorbed by the body. Some promising applications in indusSturpiapllesmusetnatainryaMbialitteyri,amls:eTdhiecafolllporwoicnegsasreesa,vaanildabelenovnilrionenamtwenwtw-r.emladtpeid.coamr/exaxsx/as1r,eVaildseoo:dFies3cOu4@ssUeiOd-.66 dispersioninthepresenceofamagnetfield. Supplementary Materials: The following are available online at http://www.mdpi.com/2073-4352/8/6/250/s1, AuthorContributions:Themanuscriptwaswrittenthroughcontributionsofallauthors.Allauthorshavegiven Video: Fe3O4@UiO-66 dispersion in the presence of a magnet field. approvaltothefinalversionofthemanuscript. Author Contributions: The manuscript was written through contributions of all authors. All authors have given approvalAckntoowtheledfinalgemeversionnt: Thisofsttheudymanuscript.has been supported by the National High Technology Research and Development Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science FoundationofChinaNo.2014CFB552;HubeiCollaborativeInnovationCenterforAdvancedOrganicChemical Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science Foundation of China MaterialsofChinaNo.000-01647909. No. 2014CFB552; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials of China No. 00C0o-n0f1l6ic4t7s9o0f9I.nterest:Theauthorsdeclarenoconflictofinterest. Funding Information: This study has been supported by the National High Technology Research and Development Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science Foundation of China No. 2014CFB552; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials of China No. 000-01647909. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = jun,

day = "15",

doi = "10.3390/cryst8060250",

language = "English (US)",

volume = "8",

journal = "Crystals",

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T1 - Magnetic MOF for AO7 removal and targeted delivery

AU - Zhan, Xue Qing

AU - Yu, Xiao Yan

AU - Tsai, Fang Chang

AU - Ma, Ning

AU - Liu, Huan Li

AU - Han, Yu

AU - Xie, Lei

AU - Jiang, Tao

AU - Shi, Dean

AU - Xiong, Yan

N1 - Funding Information: capacity (140 mg/g) comparable to the conventional UiO-66 (140 mg/g) and the release rate of the dye under the action of methanol are also considerable. By comparing the properties and structure of AO7 with similar drugs, we think some drugs such as Aspirin and Iressa can also be adsorbed by down, whichensuresthat the drugis better absorbed by the body.Some promising applicationsin Fe3O4@UiO-66. Because of the effect of pH on drug release, the rate of release is somewhat slowed industrialsustainability,medicalprocesses,andenvironment-relatedareasarealsodiscussed. down, which ensures that the drug is better absorbed by the body. Some promising applications in indusSturpiapllesmusetnatainryaMbialitteyri,amls:eTdhiecafolllporwoicnegsasreesa,vaanildabelenovnilrionenamtwenwtw-r.emladtpeid.coamr/exaxsx/as1r,eVaildseoo:dFies3cOu4@ssUeiOd-.66 dispersioninthepresenceofamagnetfield. Supplementary Materials: The following are available online at http://www.mdpi.com/2073-4352/8/6/250/s1, AuthorContributions:Themanuscriptwaswrittenthroughcontributionsofallauthors.Allauthorshavegiven Video: Fe3O4@UiO-66 dispersion in the presence of a magnet field. approvaltothefinalversionofthemanuscript. Author Contributions: The manuscript was written through contributions of all authors. All authors have given approvalAckntoowtheledfinalgemeversionnt: Thisofsttheudymanuscript.has been supported by the National High Technology Research and Development Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science FoundationofChinaNo.2014CFB552;HubeiCollaborativeInnovationCenterforAdvancedOrganicChemical Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science Foundation of China MaterialsofChinaNo.000-01647909. No. 2014CFB552; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials of China No. 00C0o-n0f1l6ic4t7s9o0f9I.nterest:Theauthorsdeclarenoconflictofinterest. Funding Information: This study has been supported by the National High Technology Research and Development Program (863 program) of China No. 2012AA06A111; Hubei Provincial Natural Science Foundation of China No. 2014CFB552; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials of China No. 000-01647909. Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2018/6/15

Y1 - 2018/6/15

N2 - Owing to their high surface area and porosity, metal-organic frameworks (MOFs) have been gradually employed for a myriad of applications ranging from sensing, pollutant adsorption, and drug delivery to environmental remediation and catalysis. Magnetic nanoparticles-metal-organic frameworks (MMOFs) hybrid materials can facilitate facile removal of MOFs from solutions. In this report, we report the synthesis of Fe3O4@UiO-66 by encapsulation and simulated the drug loading and release by studying the adsorption and release of AO7. Thus, we loaded these MMOFs with AO7 and found that they were able to trigger and control its release by simply applying an external magnetic field. The magnetic field heats the magnets in the MOF, which causes the load to burst from the framework.

AB - Owing to their high surface area and porosity, metal-organic frameworks (MOFs) have been gradually employed for a myriad of applications ranging from sensing, pollutant adsorption, and drug delivery to environmental remediation and catalysis. Magnetic nanoparticles-metal-organic frameworks (MMOFs) hybrid materials can facilitate facile removal of MOFs from solutions. In this report, we report the synthesis of Fe3O4@UiO-66 by encapsulation and simulated the drug loading and release by studying the adsorption and release of AO7. Thus, we loaded these MMOFs with AO7 and found that they were able to trigger and control its release by simply applying an external magnetic field. The magnetic field heats the magnets in the MOF, which causes the load to burst from the framework.

KW - AO7

KW - Magnetic MOFs

KW - Targeted delivery

KW - Triggered release

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U2 - 10.3390/cryst8060250

DO - 10.3390/cryst8060250

M3 - Article

AN - SCOPUS:85048729734

SN - 2073-4352

VL - 8

JO - Crystals

JF - Crystals

IS - 6

M1 - 250

ER -

Magnetic MOF for AO7 removal and targeted delivery

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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