Abstract
A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.
Original language | English (US) |
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Pages (from-to) | 3171-3175 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 74 |
Issue number | 25 |
DOIs | |
State | Published - Jun 21 2018 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Ltd
Keywords
- FTIR spectroscopy
- Flow chemistry
- Photocyclization
- Self-optimization
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry