Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

K. Poscharny; D. C. Fabry; S. Heddrich; E. Sugiono; M. A. Liauw; M. Rueping

doi:10.1016/j.tet.2018.04.019

Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

K. Poscharny, D. C. Fabry, S. Heddrich, E. Sugiono, M. A. Liauw, M. Rueping^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.

Original language	English (US)
Pages (from-to)	3171-3175
Number of pages	5
Journal	Tetrahedron
Volume	74
Issue number	25
DOIs	https://doi.org/10.1016/j.tet.2018.04.019
State	Published - Jun 21 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

FTIR spectroscopy
Flow chemistry
Photocyclization
Self-optimization

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2018.04.019

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abstract = "A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.",

keywords = "FTIR spectroscopy, Flow chemistry, Photocyclization, Self-optimization",

author = "K. Poscharny and Fabry, {D. C.} and S. Heddrich and E. Sugiono and Liauw, {M. A.} and M. Rueping",

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T2 - A self-optimizing reactor system for continuous-flow photochemical reactions

AU - Poscharny, K.

AU - Fabry, D. C.

AU - Heddrich, S.

AU - Sugiono, E.

AU - Liauw, M. A.

AU - Rueping, M.

PY - 2018/6/21

Y1 - 2018/6/21

N2 - A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.

AB - A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.

KW - FTIR spectroscopy

KW - Flow chemistry

KW - Photocyclization

KW - Self-optimization

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U2 - 10.1016/j.tet.2018.04.019

DO - 10.1016/j.tet.2018.04.019

M3 - Article

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JO - Tetrahedron

JF - Tetrahedron

IS - 25

ER -

Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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