Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

K. Poscharny; D.C. Fabry; S. Heddrich; E. Sugiono; M.A. Liauw; Magnus Rueping

doi:10.1016/j.tet.2018.04.019

Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

K. Poscharny, D.C. Fabry, S. Heddrich, E. Sugiono, M.A. Liauw, Magnus Rueping

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.

Original language	English (US)
Pages (from-to)	3171-3175
Number of pages	5
Journal	Tetrahedron
Volume	74
Issue number	25
DOIs	https://doi.org/10.1016/j.tet.2018.04.019
State	Published - Apr 7 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-04-23
Acknowledgements: Technical assistance by Cornelia Vermeeren is very gratefully acknowledged. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement No. 617044 (SunCatChem).

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10.1016/j.tet.2018.04.019

https://repository.kaust.edu.sa/bitstream/10754/627521/1/1-s2.0-S0040402018303983-main.pdf

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title = "Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions",

abstract = "A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.",

author = "K. Poscharny and D.C. Fabry and S. Heddrich and E. Sugiono and M.A. Liauw and Magnus Rueping",

note = "KAUST Repository Item: Exported on 2020-04-23 Acknowledgements: Technical assistance by Cornelia Vermeeren is very gratefully acknowledged. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement No. 617044 (SunCatChem).",

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doi = "10.1016/j.tet.2018.04.019",

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T1 - Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

AU - Poscharny, K.

AU - Fabry, D.C.

AU - Heddrich, S.

AU - Sugiono, E.

AU - Liauw, M.A.

AU - Rueping, Magnus

N1 - KAUST Repository Item: Exported on 2020-04-23 Acknowledgements: Technical assistance by Cornelia Vermeeren is very gratefully acknowledged. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement No. 617044 (SunCatChem).

PY - 2018/4/7

Y1 - 2018/4/7

N2 - A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.

AB - A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.

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DO - 10.1016/j.tet.2018.04.019

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JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

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ER -

Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

Abstract

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