Machine assisted reaction optimization: A self-optimizing reactor system for continuous-flow photochemical reactions

K. Poscharny, D. C. Fabry, S. Heddrich, E. Sugiono, M. A. Liauw, M. Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

A methodology for the synthesis of oxetanes from benzophenone and furan derivatives is presented. UV-light irradiation in batch and flow systems allowed the [2 + 2] cycloaddition reaction to proceed and a broad range of oxetanes could be synthesized in manual and automated fashion. The identification of high-yielding reaction parameters was achieved through a new self-optimizing photoreactor system.

Original languageEnglish (US)
Pages (from-to)3171-3175
Number of pages5
JournalTetrahedron
Volume74
Issue number25
DOIs
StatePublished - Jun 21 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • FTIR spectroscopy
  • Flow chemistry
  • Photocyclization
  • Self-optimization

ASJC Scopus subject areas

  • Drug Discovery
  • Biochemistry
  • Organic Chemistry

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