Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Michael R. Reithofer; Kiat Hwa Chan; Anupama Lakshmanan; Dang Hoang Lam; Archana Mishra; Began Gopalan; Mangesh Joshi; Shu Wang; Charlotte A.E. Hauser

doi:10.1039/c3sc51930a

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Michael R. Reithofer^*, Kiat Hwa Chan, Anupama Lakshmanan, Dang Hoang Lam, Archana Mishra, Began Gopalan, Mangesh Joshi, Shu Wang, Charlotte A.E. Hauser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

Original language	English (US)
Pages (from-to)	625-630
Number of pages	6
Journal	Chemical Science
Volume	5
Issue number	2
DOIs	https://doi.org/10.1039/c3sc51930a
State	Published - Feb 2014
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c3sc51930a

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title = "Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy",

abstract = "Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.",

author = "Reithofer, {Michael R.} and Chan, {Kiat Hwa} and Anupama Lakshmanan and Lam, {Dang Hoang} and Archana Mishra and Began Gopalan and Mangesh Joshi and Shu Wang and Hauser, {Charlotte A.E.}",

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language = "English (US)",

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AU - Reithofer, Michael R.

AU - Chan, Kiat Hwa

AU - Lakshmanan, Anupama

AU - Lam, Dang Hoang

AU - Mishra, Archana

AU - Gopalan, Began

AU - Joshi, Mangesh

AU - Wang, Shu

AU - Hauser, Charlotte A.E.

PY - 2014/2

Y1 - 2014/2

N2 - Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

AB - Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

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U2 - 10.1039/c3sc51930a

DO - 10.1039/c3sc51930a

M3 - Article

AN - SCOPUS:84891435877

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VL - 5

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JO - Chemical Science

JF - Chemical Science

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ER -

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Abstract

ASJC Scopus subject areas

UN SDGs

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