Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

Concepción Rodriguez-Esteban, John W.R. Schwabe, Jennifer De La Peña, Diego E. Rincon-Limas, Jorge Magallón, Juan Botas, Juan Carlos Izpisúa Belmonte

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.

Original languageEnglish (US)
Pages (from-to)3925-3934
Number of pages10
Issue number20
StatePublished - 1998
Externally publishedYes


  • Drosophila
  • Lhs2
  • Limb outgrowth
  • Lmx-1
  • Vertebrate
  • apterous

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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