Level set method for positron emission tomography

Tony F. Chan*, Hongwei Li, Marius Lysaker, Xue Cheng Tai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


In positron emission tomography (PET), a radioactive compound is injected into the body to promote a tissue-dependent emission rate.Expectation maximization (EM) reconstruction algorithms are iterative techniques which estimate the concentration coefficients that provide the best fitted solution, for example, a maximum likelihood estimate. In this paper, we combine the EM algorithm with a level set approach.The level set method is used to capture the coarse scale information and the discontinuities of the concentration coefficients.An intrinsic advantage of the level set formulation is that anatomical information can be efficiently incorporated and used in an easy and natural way.We utilize a multiple level set formulation to represent the geometry of the objects in the scene. The proposed algorithm can be applied to any PET configuration, without major modifications.

Original languageEnglish (US)
Article number26950
JournalInternational Journal of Biomedical Imaging
StatePublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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