LEAfing through literature: late embryogenesis abundant proteins coming of age - achievements and perspectives

Itzell E. Hernández-Sánchez, Israel Maruri-López, Coral Martinez-Martinez, Brett Janis, Juan Francisco Jiménez-Bremont, Alejandra A. Covarrubias, Michael A. Menze, Steffen P. Graether, Anja Thalhammer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

To deal with increasingly severe periods of dehydration related to global climate change, it becomes increasingly important to understand the complex strategies many organisms have developed to cope with dehydration and desiccation. While it is undisputed that late embryogenesis abundant (LEA) proteins play a key role in the tolerance of plants and many anhydrobiotic organisms to water limitation, the molecular mechanisms are not well understood. In this review, we summarize current knowledge of the physiological roles of LEA proteins and discuss their potential molecular functions. As these are ultimately linked to conformational changes in the presence of binding partners, post-translational modifications, or water deprivation, we provide a detailed summary of current knowledge on the structure-function relationship of LEA proteins, including their disordered state in solution, coil to helix transitions, self-assembly, and their recently discovered ability to undergo liquid-liquid phase separation. We point out the promising potential of LEA proteins in biotechnological and agronomic applications, and summarize recent advances. We identify the most relevant open questions and discuss major challenges in establishing a solid understanding of how these intriguing molecules accomplish their tasks as cellular sentinels at the limits of surviving water scarcity.

Original languageEnglish (US)
Pages (from-to)6525-6546
Number of pages22
JournalJournal of experimental botany
Volume73
Issue number19
DOIs
StatePublished - Nov 2 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved.

Keywords

  • Abiotic stress tolerance
  • anhydrobiosis
  • dehydration
  • desiccation
  • intrinsically disordered protein
  • LEA protein
  • liquid-liquid phase separation
  • post-translational modification

ASJC Scopus subject areas

  • Physiology
  • Plant Science

Fingerprint

Dive into the research topics of 'LEAfing through literature: late embryogenesis abundant proteins coming of age - achievements and perspectives'. Together they form a unique fingerprint.

Cite this