Layer 1 neocortex: Gating and integrating multidimensional signals

Shuhan Huang, Sherry Jingjing Wu, Giulia Sansone, Leena Ali Ibrahim*, Gord Fishell*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Layer 1 (L1) of the neocortex acts as a nexus for the collection and processing of widespread information. By integrating ascending inputs with extensive top-down activity, this layer likely provides critical information regulating how the perception of sensory inputs is reconciled with expectation. This is accomplished by sorting, directing, and integrating the complex network of excitatory inputs that converge onto L1. These signals are combined with neuromodulatory afferents and gated by the wealth of inhibitory interneurons that either are embedded within L1 or send axons from other cortical layers. Together, these interactions dynamically calibrate information flow throughout the neocortex. This review will primarily focus on L1 within the primary sensory cortex and will use these insights to understand L1 in other cortical areas.

Original languageEnglish (US)
Pages (from-to)184-200
Number of pages17
Issue number2
StatePublished - Jan 17 2024

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc.


  • cortex
  • dendrite
  • inhibitory interneuron
  • integration
  • layer 1
  • neuromodulation
  • sensory cortex
  • state
  • top-down

ASJC Scopus subject areas

  • General Neuroscience


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