Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals.

Mohamed E Abd El-Hack, Sameh A Abdelnour, Mahmoud Kamal, Asmaa F Khafaga, Afnan M Shakoori, Rehab M Bagadood, Hind M Naffadi, Areej Y Alyahyawi, Hanan Khojah, Saleh Alghamdi, Mariusz Jaremko, Sylwester Świątkiewicz

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Lactoferrin (LF) is a protein found in several bodily fluids, such as milk. This protein has a diverse range of functions and is evolutionarily conserved. Lactoferrin is a multifunction protein with distinct biological abilities affecting mammals' immune structures. Reports indicated that the daily uptake of LF from dairy products is unsatisfactory in detecting further health-promoting abilities. Research has shown that it protects against infection, mitigates cellular senescence, and improves nutritional quality. Additionally, LF is being studied as a potential treatment for various diseases and conditions, including gastrointestinal issues and infections. Studies have also demonstrated its effectiveness against various viruses and bacteria. In this article, we'll look closer at the structure of LF and its various biological activities, including its antimicrobial, anti-viral, anti-cancer, anti-osteoporotic, detoxifying, and immunomodulatory properties. More specifically, the protective effect of LF against oxidative DNA damage was also clarified through its ability to abolish DNA damaging issues without interfacing with host genetic material. Fortification with LF protects mitochondria dysfunction syndromes via sustaining redox status and biogenesis and suppressing apoptosis and autophagy singling. Additionally, we'll examine the potential benefits of lactoferrin and provide an overview of recent clinical trials conducted to examine its use in laboratory and living models.
Original languageEnglish (US)
Pages (from-to)114967
JournalBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Volume164
DOIs
StatePublished - Jun 6 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-06-12
Acknowledgements: The authors thank their respective institutes and universities for their help.

ASJC Scopus subject areas

  • Pharmacology

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