Label-free detection of DNA hybridization using transistors based on CVD grown graphene

Tzu Yin Chen, Phan Thi Kim Loan, Chang Lung Hsu, Yi Hsien Lee, Jacob Tse-Wei Wang, Kung Hwa Wei, Cheng Te Lin*, Lain Jong Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

190 Scopus citations


The high transconductance and low noise of graphene-based field-effect transistors based on large-area monolayer graphene produced by chemical vapor deposition are used for label-free electrical detection of DNA hybridization. The gate materials, buffer concentration and surface condition of graphene have been optimized to achieve the DNA detection sensitivity as low as 1pM (10-12M), which is more sensitive than the existing report based on few-layer graphene. The graphene films obtained using conventional PMMA-assisted transfer technique exhibits PMMA residues, which degrade the sensing performance of graphene. We have demonstrated that the sensing performance of the graphene samples prepared by gold-transfer is largely enhanced (by 125%).

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalBiosensors and Bioelectronics
Issue number1
StatePublished - Mar 15 2013
Externally publishedYes


  • CVD graphene
  • DNA sensing
  • Gold-transfer method
  • Label-free detection
  • Liquid-gated transistors

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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