l-Lactate: Food for Thoughts, Memory and Behavior.

Maria Fernanda Veloz Castillo, Pierre J. Magistretti, Corrado Cali

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


More and more evidence shows how brain energy metabolism is the linkage between physiological and morphological synaptic plasticity and memory consolidation. Different types of memory are associated with differential inputs, each with specific inputs that are upstream diverse molecular cascades depending on the receptor activity. No matter how heterogeneous the response is, energy availability represents the lowest common denominator since all these mechanisms are energy consuming and the brain networks adapt their performance accordingly. Astrocytes exert a primary role in this sense by acting as an energy buffer; glycogen granules, a mechanism to store glucose, are redistributed at glance and conveyed to neurons via the Astrocyte-Neuron Lactate Shuttle (ANLS). Here, we review how different types of memory relate to the mechanisms of energy delivery in the brain.
Original languageEnglish (US)
Pages (from-to)548
Issue number8
StatePublished - Aug 26 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-08-30
Acknowledgements: We thank Matthew Fechtmeyer (English Language and Communication Program, KAUST) for critical review and grammatical editing of the manuscript.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism


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