Isogeometric fluid-structure interaction analysis with applications to arterial blood flow

Y. Bazilevs, V. M. Calo, Y. Zhang, T. J.R. Hughes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

593 Scopus citations


A NURBS (non-uniform rational B-splines)-based isogeometric fluid-structure interaction formulation, coupling incompressible fluids with non-linear elastic solids, and allowing for large structural displacements, is developed. This methodology, encompassing a very general class of applications, is applied to problems of arterial blood flow modeling and simulation. In addition, a set of procedures enabling the construction of analysis-suitable NURBS geometries directly from patient-specific imaging data is outlined. The approach is compared with representative benchmark problems, yielding very good results. Computation of a patient-specific abdominal aorta is also performed, giving qualitative agreement with computations by other researchers using similar models.

Original languageEnglish (US)
Pages (from-to)310-322
Number of pages13
JournalComputational Mechanics
Issue number4-5
StatePublished - Sep 2006
Externally publishedYes


  • Blood flow
  • Elastic arterial wall
  • Fluid-structure interaction
  • Isogeometric analysis
  • Mesh movement
  • Navier-Stokes equations
  • Vascular modeling

ASJC Scopus subject areas

  • Computational Mechanics
  • Ocean Engineering
  • Mechanical Engineering
  • Computational Theory and Mathematics
  • Computational Mathematics
  • Applied Mathematics


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