Iridium-Catalyzed Reductive Amination of Levulinic Acid to Pyrrolidinones under H2 in Water

Zhanwei Xu, Peifang Yan, Hong Jiang, Kairui Liu, Z. Conrad Zhang

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The synthesis of pyrrolidinones from reductive amination of levulinic acid (LA) with primary amines is reported. Pyrrolidinones have various applications such as surfactants, pharmaceutical intermediates, dispersants, and solvents. The half-sandwich Cp*Ir complex (Cp* is 1,2,3,4,5-pentamethylcyclopenta-1,3-diene) coordinated by bipyridine ligand bearing both dimethylamino and ortho-hydroxyl groups showed high catalytic activity for the reductive amination of LA. A range of primary amines, such as aromatic and benzyl amines, were readily converted to corresponding pyrrolidinones in good yields.
Original languageEnglish (US)
Pages (from-to)581-585
Number of pages5
JournalChinese Journal of Chemistry
Volume35
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

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Generated from Scopus record by KAUST IRTS on 2023-10-22

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