iPSC disease modeling of laminopathies

Guang Hui Liu; Jiping Yang; Zhichao Ding; Alejandro Ocampo; Jing Qu; Keiichiro Suzuki; Juan Carlos Izpisua Belmonte

doi:10.1007/978-4-431-55966-5_5

iPSC disease modeling of laminopathies

Guang Hui Liu^*, Jiping Yang, Zhichao Ding, Alejandro Ocampo, Jing Qu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Nuclear lamins, the major components of the nuclear lamina, participate in maintaining the nuclear structure and are involved in essential cellular processes, including DNA replication and chromatin organization. To date, more than 15 human diseases classified as laminopathies have been linked to mutations in components of the nuclear lamina. With the development of induced pluripotent stem cell (iPSC) and targeted gene editing technologies, novel disease models of laminopathies have been generated. These models will improve our understanding of the pathological mechanism of laminopathies and may eventually lead to the discovery of new therapeutic approaches for the treatment of these devastating diseases.

Original language	English (US)
Title of host publication	Human iPS Cells in Disease Modelling
Publisher	Springer Japan
Pages	53-67
Number of pages	15
ISBN (Electronic)	9784431559665
ISBN (Print)	9784431559641
DOIs	https://doi.org/10.1007/978-4-431-55966-5_5
State	Published - Jan 1 2016

Bibliographical note

Publisher Copyright:
© Springer Japan 2016.

Keywords

Disease model
IPSC
Laminopathy

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-55966-5_5

Cite this

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abstract = "Nuclear lamins, the major components of the nuclear lamina, participate in maintaining the nuclear structure and are involved in essential cellular processes, including DNA replication and chromatin organization. To date, more than 15 human diseases classified as laminopathies have been linked to mutations in components of the nuclear lamina. With the development of induced pluripotent stem cell (iPSC) and targeted gene editing technologies, novel disease models of laminopathies have been generated. These models will improve our understanding of the pathological mechanism of laminopathies and may eventually lead to the discovery of new therapeutic approaches for the treatment of these devastating diseases.",

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AU - Liu, Guang Hui

AU - Yang, Jiping

AU - Ding, Zhichao

AU - Ocampo, Alejandro

AU - Qu, Jing

AU - Suzuki, Keiichiro

AU - Belmonte, Juan Carlos Izpisua

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N2 - Nuclear lamins, the major components of the nuclear lamina, participate in maintaining the nuclear structure and are involved in essential cellular processes, including DNA replication and chromatin organization. To date, more than 15 human diseases classified as laminopathies have been linked to mutations in components of the nuclear lamina. With the development of induced pluripotent stem cell (iPSC) and targeted gene editing technologies, novel disease models of laminopathies have been generated. These models will improve our understanding of the pathological mechanism of laminopathies and may eventually lead to the discovery of new therapeutic approaches for the treatment of these devastating diseases.

AB - Nuclear lamins, the major components of the nuclear lamina, participate in maintaining the nuclear structure and are involved in essential cellular processes, including DNA replication and chromatin organization. To date, more than 15 human diseases classified as laminopathies have been linked to mutations in components of the nuclear lamina. With the development of induced pluripotent stem cell (iPSC) and targeted gene editing technologies, novel disease models of laminopathies have been generated. These models will improve our understanding of the pathological mechanism of laminopathies and may eventually lead to the discovery of new therapeutic approaches for the treatment of these devastating diseases.

KW - Disease model

KW - IPSC

KW - Laminopathy

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EP - 67

BT - Human iPS Cells in Disease Modelling

PB - Springer Japan

ER -

iPSC disease modeling of laminopathies

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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