IPS cells forgive but do not forget

Maria J. Barrero, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations


Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

Original languageEnglish (US)
Pages (from-to)523-525
Number of pages3
JournalNature Cell Biology
Issue number5
StatePublished - May 2011
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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