Investigating the Biological Activity of Imidazolium Aurate Salts

Eleni Sioriki; Sylvain Gaillard; Fady Nahra; Rehan Imad; Khair Ullah; Sheeba Wajid; Danish Sharif; Sharmeen Fayyaz; Fiza Arshad; M. Iqbal Choudhary; Steven P. Nolan

doi:10.1002/slct.201903435

Investigating the Biological Activity of Imidazolium Aurate Salts

Eleni Sioriki, Sylvain Gaillard, Fady Nahra, Rehan Imad, Khair Ullah, Sheeba Wajid, Danish Sharif, Sharmeen Fayyaz, Fiza Arshad, M. Iqbal Choudhary, Steven P. Nolan

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report herein the biological activities of several imidazolium aurate(I) salts. The cytotoxicity on three cell-lines (i. e. Hela, H460 and 3T3), enzyme inhibition on a panel of five enzymes (i. e. prolyl endopeptidase, butyrylcholinesterase, tyrosinase, dipeptidyl peptidase and carbonic anhydrase), iron chelation and in vitro Leishmanicidal assay for promastigotes are described. A comparison with other data found in the literature using similar standards to our control experiment is also discussed. Finally, all these data lead us to establish some structure-activity correlations and to determine the potential importance of the gold moiety in these salts.

Original language	English (US)
Pages (from-to)	11061-11065
Number of pages	5
Journal	ChemistrySelect
Volume	4
Issue number	37
DOIs	https://doi.org/10.1002/slct.201903435
State	Published - Oct 2 2019
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported in part by the international center for Chemical and Biological Sciences, University of Karachi. We thank King Saud University (Distinguished Scientist Fellowship Program) and King Abdullah University of Science and Technology (Award No.OSR-2015-CCF-1974-03) for support.

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title = "Investigating the Biological Activity of Imidazolium Aurate Salts",

abstract = "We report herein the biological activities of several imidazolium aurate(I) salts. The cytotoxicity on three cell-lines (i. e. Hela, H460 and 3T3), enzyme inhibition on a panel of five enzymes (i. e. prolyl endopeptidase, butyrylcholinesterase, tyrosinase, dipeptidyl peptidase and carbonic anhydrase), iron chelation and in vitro Leishmanicidal assay for promastigotes are described. A comparison with other data found in the literature using similar standards to our control experiment is also discussed. Finally, all these data lead us to establish some structure-activity correlations and to determine the potential importance of the gold moiety in these salts.",

author = "Eleni Sioriki and Sylvain Gaillard and Fady Nahra and Rehan Imad and Khair Ullah and Sheeba Wajid and Danish Sharif and Sharmeen Fayyaz and Fiza Arshad and Choudhary, {M. Iqbal} and Nolan, {Steven P.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported in part by the international center for Chemical and Biological Sciences, University of Karachi. We thank King Saud University (Distinguished Scientist Fellowship Program) and King Abdullah University of Science and Technology (Award No.OSR-2015-CCF-1974-03) for support.",

year = "2019",

month = oct,

day = "2",

doi = "10.1002/slct.201903435",

language = "English (US)",

volume = "4",

pages = "11061--11065",

journal = "ChemistrySelect",

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T1 - Investigating the Biological Activity of Imidazolium Aurate Salts

AU - Sioriki, Eleni

AU - Gaillard, Sylvain

AU - Nahra, Fady

AU - Imad, Rehan

AU - Ullah, Khair

AU - Wajid, Sheeba

AU - Sharif, Danish

AU - Fayyaz, Sharmeen

AU - Arshad, Fiza

AU - Choudhary, M. Iqbal

AU - Nolan, Steven P.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported in part by the international center for Chemical and Biological Sciences, University of Karachi. We thank King Saud University (Distinguished Scientist Fellowship Program) and King Abdullah University of Science and Technology (Award No.OSR-2015-CCF-1974-03) for support.

PY - 2019/10/2

Y1 - 2019/10/2

N2 - We report herein the biological activities of several imidazolium aurate(I) salts. The cytotoxicity on three cell-lines (i. e. Hela, H460 and 3T3), enzyme inhibition on a panel of five enzymes (i. e. prolyl endopeptidase, butyrylcholinesterase, tyrosinase, dipeptidyl peptidase and carbonic anhydrase), iron chelation and in vitro Leishmanicidal assay for promastigotes are described. A comparison with other data found in the literature using similar standards to our control experiment is also discussed. Finally, all these data lead us to establish some structure-activity correlations and to determine the potential importance of the gold moiety in these salts.

AB - We report herein the biological activities of several imidazolium aurate(I) salts. The cytotoxicity on three cell-lines (i. e. Hela, H460 and 3T3), enzyme inhibition on a panel of five enzymes (i. e. prolyl endopeptidase, butyrylcholinesterase, tyrosinase, dipeptidyl peptidase and carbonic anhydrase), iron chelation and in vitro Leishmanicidal assay for promastigotes are described. A comparison with other data found in the literature using similar standards to our control experiment is also discussed. Finally, all these data lead us to establish some structure-activity correlations and to determine the potential importance of the gold moiety in these salts.

UR - http://hdl.handle.net/10754/661432

UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201903435

UR - http://www.scopus.com/inward/record.url?scp=85074138451&partnerID=8YFLogxK

U2 - 10.1002/slct.201903435

DO - 10.1002/slct.201903435

M3 - Article

SN - 2365-6549

VL - 4

SP - 11061

EP - 11065

JO - ChemistrySelect

JF - ChemistrySelect

IS - 37

ER -

Investigating the Biological Activity of Imidazolium Aurate Salts

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