Intrinsic function of a neuronal network - A vertebrate central pattern generator

Sten Grillner; Örjan Ekeberg; Abdeljabbar El Manira; Anders Lansner; David Parker; Jesper Tegnér; Peter Wallén

doi:10.1016/S0165-0173(98)00002-2

Intrinsic function of a neuronal network - A vertebrate central pattern generator

Sten Grillner^*, Örjan Ekeberg, Abdeljabbar El Manira, Anders Lansner, David Parker, Jesper Tegnér, Peter Wallén

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

216 Scopus citations

Abstract

The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca²⁺ channels, Ca²⁺ dependent K⁺ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level.

Original language	English (US)
Pages (from-to)	184-197
Number of pages	14
Journal	Brain Research Reviews
Volume	26
Issue number	2-3
DOIs	https://doi.org/10.1016/S0165-0173(98)00002-2
State	Published - May 1998
Externally published	Yes

Keywords

Glutamate
Glycine
Ion channels
Locomotion
Modellin
Networks
Tachykinin

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/S0165-0173(98)00002-2

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title = "Intrinsic function of a neuronal network - A vertebrate central pattern generator",

abstract = "The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca2+ channels, Ca2+ dependent K+ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level.",

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year = "1998",

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T1 - Intrinsic function of a neuronal network - A vertebrate central pattern generator

AU - Grillner, Sten

AU - Ekeberg, Örjan

AU - El Manira, Abdeljabbar

AU - Lansner, Anders

AU - Parker, David

AU - Tegnér, Jesper

AU - Wallén, Peter

PY - 1998/5

Y1 - 1998/5

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AB - The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca2+ channels, Ca2+ dependent K+ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level.

KW - Glutamate

KW - Glycine

KW - Ion channels

KW - Locomotion

KW - Modellin

KW - Networks

KW - Tachykinin

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VL - 26

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EP - 197

JO - Brain Research Reviews

JF - Brain Research Reviews

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ER -

Intrinsic function of a neuronal network - A vertebrate central pattern generator

Abstract

Keywords

ASJC Scopus subject areas

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