Intrinsic function of a neuronal network - A vertebrate central pattern generator

Sten Grillner*, Örjan Ekeberg, Abdeljabbar El Manira, Anders Lansner, David Parker, Jesper Tegnér, Peter Wallén

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

216 Scopus citations


The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca2+ channels, Ca2+ dependent K+ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level.

Original languageEnglish (US)
Pages (from-to)184-197
Number of pages14
JournalBrain Research Reviews
Issue number2-3
StatePublished - May 1998
Externally publishedYes


  • Glutamate
  • Glycine
  • Ion channels
  • Locomotion
  • Modellin
  • Networks
  • Tachykinin

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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