Intramolecularly stapled amphiphatic peptides via boron-sugar interaction

Monika Kijewska; Angelika Czerwinska; Samah Al-Harthi; Grzegorz Wołczański; Mateusz Waliczek; Abdul-Hamid M. Emwas; Mariusz Jaremko; Lukasz Jaremko; Piotr Stefanowicz; Zbigniew Szewczuk

doi:10.1039/d0cc02603d

Intramolecularly stapled amphiphatic peptides via boron-sugar interaction

Monika Kijewska, Angelika Czerwinska, Samah Al-Harthi, Grzegorz Wołczański, Mateusz Waliczek, Abdul-Hamid M. Emwas, Mariusz Jaremko, Lukasz Jaremko, Piotr Stefanowicz, Zbigniew Szewczuk

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated in various positions of peptide chain was investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).

Original language	English (US)
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/d0cc02603d
State	Published - Jun 23 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by Grant No.UMO2015/19/B/ST5/00659 from the National Science Centre, Poland. The authors would like to thank Andrzej Reszka (ShimPol, Poland) for providing the Shimadzu LCMS-IT-TOF. LJ, MJ, SMA, and A-HE would like to thank the King Abdullah University of Science and Technology (KAUST) for financial support.

Access to Document

10.1039/d0cc02603d

https://repository.kaust.edu.sa/bitstream/10754/663873/1/Intramolecular.pdf

Cite this

@article{c67a9748b3e14fe3ac6ca23b24679b92,

title = "Intramolecularly stapled amphiphatic peptides via boron-sugar interaction",

abstract = "Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated in various positions of peptide chain was investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).",

author = "Monika Kijewska and Angelika Czerwinska and Samah Al-Harthi and Grzegorz Wo{\l}cza{\'n}ski and Mateusz Waliczek and Emwas, {Abdul-Hamid M.} and Mariusz Jaremko and Lukasz Jaremko and Piotr Stefanowicz and Zbigniew Szewczuk",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by Grant No.UMO2015/19/B/ST5/00659 from the National Science Centre, Poland. The authors would like to thank Andrzej Reszka (ShimPol, Poland) for providing the Shimadzu LCMS-IT-TOF. LJ, MJ, SMA, and A-HE would like to thank the King Abdullah University of Science and Technology (KAUST) for financial support.",

year = "2020",

month = jun,

day = "23",

doi = "10.1039/d0cc02603d",

language = "English (US)",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

}

TY - JOUR

T1 - Intramolecularly stapled amphiphatic peptides via boron-sugar interaction

AU - Kijewska, Monika

AU - Czerwinska, Angelika

AU - Al-Harthi, Samah

AU - Wołczański, Grzegorz

AU - Waliczek, Mateusz

AU - Emwas, Abdul-Hamid M.

AU - Jaremko, Mariusz

AU - Jaremko, Lukasz

AU - Stefanowicz, Piotr

AU - Szewczuk, Zbigniew

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by Grant No.UMO2015/19/B/ST5/00659 from the National Science Centre, Poland. The authors would like to thank Andrzej Reszka (ShimPol, Poland) for providing the Shimadzu LCMS-IT-TOF. LJ, MJ, SMA, and A-HE would like to thank the King Abdullah University of Science and Technology (KAUST) for financial support.

PY - 2020/6/23

Y1 - 2020/6/23

N2 - Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated in various positions of peptide chain was investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).

AB - Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated in various positions of peptide chain was investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).

UR - http://hdl.handle.net/10754/663873

UR - http://pubs.rsc.org/en/Content/ArticleLanding/2020/CC/D0CC02603D

U2 - 10.1039/d0cc02603d

DO - 10.1039/d0cc02603d

M3 - Article

C2 - 32627786

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Intramolecularly stapled amphiphatic peptides via boron-sugar interaction

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this