Intramolecular crosstalk between catalytic activities of receptor kinases

Lusisizwe Kwezi, Janet I. Wheeler, Claudius Marondedze, Chris Gehring, Helen R. Irving*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Signal modulation is important for the growth and development of plants and this process is mediated by a number of factors including physiological growth regulators and their associated signal transduction pathways. Protein kinases play a central role in signaling, including those involving pathogen response mechanisms. We previously demonstrated an active guanylate cyclase (GC) catalytic center in the brassinosteroid insensitive receptor (AtBRI1) within an active intracellular kinase domain resulting in dual enzymatic activity. Here we propose a novel type of receptor architecture that is characterized by a functional GC catalytic center nested in the cytosolic kinase domain enabling intramolecular crosstalk. This may be through a cGMP-AtBRI1 complex forming that may induce a negative feedback mechanism leading to desensitisation of the receptor, regulated through the cGMP production pathway. We further argue that the comparatively low but highly localized cGMP generated by the GC in response to a ligand is sufficient to modulate the kinase activity. This type of receptor therefore provides a molecular switch that directly and/or indirectly affects ligand dependent phosphorylation of downstream signaling cascades and suggests that subsequent signal transduction and modulation works in conjunction with the kinase in downstream signaling.

Original languageEnglish (US)
Article numbere1430544
JournalPlant Signaling and Behavior
Issue number2
StatePublished - Feb 1 2018

Bibliographical note

Publisher Copyright:
© 2018 Taylor & Francis Group, LLC.


  • Auto-regulation
  • PeP1 receptor (PEPR1)
  • brassinosteroid receptor (BRI1)
  • cyclic GMP
  • intramolecular crosstalk
  • phosphorylation
  • phytosulfokine receptor 1 (PSKR1)
  • receptor kinase
  • signal transduction

ASJC Scopus subject areas

  • Plant Science


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