Intragenic recombinations in rotaviruses

Yoshiyuki Suzuki, Takashi Gojobori*, Osamu Nakagomi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


In this paper, evidence for intragenic recombination in the VP7 gene between rotavirus strains bearing different serotypes is demonstrated for the first time. Intragenic recombination may be one of the escaping mechanisms from the host immune system for rotavirus. This process involves exchanging antigenic regions, thus questioning the use of multivalent vaccines for the prevention of rotavirus infection.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalFEBS Letters
Issue number2
StatePublished - May 8 1998
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to Prof. Hiroshi Ushijima at Tokyo University, Japan, for providing sequence data. We thank Dr. Silvana Gaudieri at National Institute of Genetics, Japan, for valuable comments on the manuscript. This study was supported, in part, by the Ministry of Education, Science, Sport, and Culture of Japan.


  • Evolution
  • Intragenic recombination
  • Rotavirus
  • Vaccine

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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