Abstract
In this paper, evidence for intragenic recombination in the VP7 gene between rotavirus strains bearing different serotypes is demonstrated for the first time. Intragenic recombination may be one of the escaping mechanisms from the host immune system for rotavirus. This process involves exchanging antigenic regions, thus questioning the use of multivalent vaccines for the prevention of rotavirus infection.
Original language | English (US) |
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Pages (from-to) | 183-187 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 427 |
Issue number | 2 |
DOIs | |
State | Published - May 8 1998 |
Externally published | Yes |
Bibliographical note
Funding Information:We are grateful to Prof. Hiroshi Ushijima at Tokyo University, Japan, for providing sequence data. We thank Dr. Silvana Gaudieri at National Institute of Genetics, Japan, for valuable comments on the manuscript. This study was supported, in part, by the Ministry of Education, Science, Sport, and Culture of Japan.
Keywords
- Evolution
- Intragenic recombination
- Rotavirus
- Vaccine
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology