Intracellular spatial control of fluorescent magnetic nanoparticles

Jinhao Gao; Wei Zhang; Pingbo Huang; Bei Zhang; Xixiang Zhang; Bing Xu

doi:10.1021/ja7103125

Intracellular spatial control of fluorescent magnetic nanoparticles

Jinhao Gao, Wei Zhang, Pingbo Huang, Bei Zhang, Xixiang Zhang, Bing Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

244 Scopus citations

Abstract

We report a facile intracellular manipulation of fluorescent magnetic Fe₃O₄-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe₃O₄ nanoparticles produces Fe₃O₄-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe₃O₄-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.

Original language	English (US)
Pages (from-to)	3710-3711
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	12
DOIs	https://doi.org/10.1021/ja7103125
State	Published - Mar 26 2008
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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10.1021/ja7103125

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title = "Intracellular spatial control of fluorescent magnetic nanoparticles",

abstract = "We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.",

author = "Jinhao Gao and Wei Zhang and Pingbo Huang and Bei Zhang and Xixiang Zhang and Bing Xu",

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TY - JOUR

T1 - Intracellular spatial control of fluorescent magnetic nanoparticles

AU - Gao, Jinhao

AU - Zhang, Wei

AU - Huang, Pingbo

AU - Zhang, Bei

AU - Zhang, Xixiang

AU - Xu, Bing

PY - 2008/3/26

Y1 - 2008/3/26

N2 - We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.

AB - We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.

UR - http://www.scopus.com/inward/record.url?scp=41149131679&partnerID=8YFLogxK

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DO - 10.1021/ja7103125

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EP - 3711

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 12

ER -

Intracellular spatial control of fluorescent magnetic nanoparticles

Abstract

ASJC Scopus subject areas

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