Interactions of a Photochromic Spiropyran with Liposome Model Membranes

Fabian Jonsson, Tamás Beke-Somfai, Joakim Andréasson, Bengt Nordén

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The interactions between anionic or zwitterionic liposomes and a water-soluble, DNA-binding photochromic spiropyran are studied using UV/vis absorption and linear dichroism (LD) spectroscopy. The spectral characteristics as well as the kinetics of the thermal isomerization process in the absence and presence of the two different liposome types provide information about the environment and whether or not the spiropyran resides in the liposome membrane. By measuring LD on liposomes deformed and aligned by shear flow, further insight is obtained about interaction and binding geometry of the spiropyran at the lipid membranes. We show that the membrane interactions differ between the two types of liposomes used as well as the isomeric forms of the spiropyran photoswitch. © 2013 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)2099-2103
Number of pages5
Issue number7
StatePublished - Feb 4 2013
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors gratefully acknowledge the help with synthesis by Dr. Shiming Li. This work was funded by the King Abdullah University of Science and Technology (KAUST Kuk No1) and by the European Research Council (ERC).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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