Abstract
P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule.
Original language | English (US) |
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Pages (from-to) | 532-539 |
Number of pages | 8 |
Journal | Nature Immunology |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - May 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology