Theileria are tick-transmitted parasites that cause often fatal leuko-proliferative diseases in cattle called tropical theileriosis (T. annulata) and East Coast fever (T. parva). However, upon treatment with anti-theilerial drug-transformed leukocytes die of apoptosis indicating that Theileria-induced transformation is reversible making infected leukocytes a powerful example of how intracellular parasites interact with their hosts. Theileria-transformed leukocytes disseminate throughout infected cattle causing a cancer-like disease and here, we discuss how cytokines, noncoding RNAs and oncometabolites can contribute to the transformed phenotype and disease pathology.
|Original language||English (US)|
|State||Published - Feb 9 2021|
Bibliographical noteKAUST Repository Item: Exported on 2021-02-15
Acknowledged KAUST grant number(s): OSR-2015-CRG4-2610
Acknowledgements: ST and TS acknowledge postdoctoral fellowships from ParaFrap (ANR-11-LABX-0024) and MH postdoctoral funding from a Competitive Research Grant from the Office for Sponsored Research (OSR-2015-CRG4-2610) at King Abdullah University of Science and Technology (KAUST) awarded to Arnab Pain and GL. The RNAseq data in Figure 2 were generated by MH, while a post-doc in Arnab Pain’s laboratory. GL also acknowledges ANR-11-LABX-0024 and core support from INSERM and the CNRS.