Integration of fractal biosensor in a digital microfluidic platform

Yousof Mashraei; Shilpa Sivashankar; Ulrich Buttner; Khaled N. Salama

doi:10.1109/ICSENS.2015.7370497

Integration of fractal biosensor in a digital microfluidic platform

Yousof Mashraei, Shilpa Sivashankar, Ulrich Buttner, Khaled N. Salama

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

8 Scopus citations

Abstract

Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.

Original language	English (US)
Title of host publication	2015 IEEE SENSORS
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
ISBN (Print)	9781479982035
DOIs	https://doi.org/10.1109/ICSENS.2015.7370497
State	Published - Jan 7 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/ICSENS.2015.7370497

https://repository.kaust.edu.sa/bitstream/10754/594971/1/IEEE%20Sensors%20Paper_Y.%20Mashraei_Fractal_Biosensor_1079.pdf

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title = "Integration of fractal biosensor in a digital microfluidic platform",

abstract = "Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.",

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AU - Mashraei, Yousof

AU - Sivashankar, Shilpa

AU - Buttner, Ulrich

AU - Salama, Khaled N.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2016/1/7

Y1 - 2016/1/7

N2 - Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.

AB - Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.

UR - http://hdl.handle.net/10754/594971

UR - http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7370497

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U2 - 10.1109/ICSENS.2015.7370497

DO - 10.1109/ICSENS.2015.7370497

M3 - Conference contribution

SN - 9781479982035

BT - 2015 IEEE SENSORS

PB - Institute of Electrical and Electronics Engineers (IEEE)

ER -

Integration of fractal biosensor in a digital microfluidic platform

Abstract

Bibliographical note

UN SDGs

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