Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques.

Zafar Ali Shah, Khalid Khan, Haroon Ur Rashid, Tanzeel Shah, Mariusz Jaremko, Zafar Iqbal

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background Recently, numerous novel bioactive fungal metabolites have been identified that possess broad therapeutic activities including anti-inflammatory, antibiotic, antioxidant, and antitumor. The fungal mycochemicals as well as extracts have increased the interest of the scientific community in drug discovery research through a combination approach such as, molecular metabolic, pharmacological and computational techniques. Therefore, the natural fungus Aspergillus ficuum (A. ficuum) (FCBP-DNA-1266) was selected for metabolic and pharmacological profiling in this study. Results The metabolic profile of A. ficuum was explored for the first time and revealed the presence of bioactive compounds such as choline sulfate, noruron, hydroxyvittatine, aurasperone D, cetrimonium, kurilensoside, heneicosane, nonadecane and eicosane. Similarly, a pharmacological screen of A. ficuum was performed for the first time in in vivo and in vitro models. Interestingly, both the ethyl acetate and n-hexane fractions of A. ficuum were found to be more active against Bacillus subtilis among five tested bacteria with their zone of inhibition (ZOI) values of 21.00 mm ±1.00 and 23.00 mm ±1.00, at a concentration of 150 μgmL-1 respectively. Similarly, a significant decrease (P
Original languageEnglish (US)
JournalBMC Microbiology
Volume22
Issue number1
DOIs
StatePublished - Dec 9 2022

Bibliographical note

KAUST Repository Item: Exported on 2022-12-13
Acknowledgements: The authors acknowledge the support of the School of Animal and Veterinary Sciences, Charles Sturt University, Wagga, Australia for LC-QToF-MS analysis.

ASJC Scopus subject areas

  • Microbiology (medical)

Fingerprint

Dive into the research topics of 'Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques.'. Together they form a unique fingerprint.

Cite this