Induced pluripotent stem cells and reprogramming: Seeing the science through the hype

Juan Carlos Izpisua Belmonte, James Ellis, Konrad Hochedlinger, Shinya Yamanaka

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.

Original languageEnglish (US)
Pages (from-to)878-883
Number of pages6
JournalNature Reviews Genetics
Issue number12
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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