TY - JOUR
T1 - In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit
AU - Ashraf, Ayesha
AU - Sharif, Rehana
AU - Ahmad, Munir
AU - Masood, Misbah
AU - Shahid, Abubakar
AU - Anjum, Dalaver H.
AU - Rafique, Muhammad Shahid
AU - Ghani, Sheeba
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. © 2015 The Institution of Engineering and Technology.
AB - Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. © 2015 The Institution of Engineering and Technology.
UR - http://hdl.handle.net/10754/594278
UR - http://www.crossref.org/iPage?doi=10.1049%2Fiet-nbt.2014.0075
UR - http://www.scopus.com/inward/record.url?scp=84949566447&partnerID=8YFLogxK
U2 - 10.1049/iet-nbt.2014.0075
DO - 10.1049/iet-nbt.2014.0075
M3 - Article
C2 - 26647813
SN - 1751-8741
VL - 9
SP - 368
EP - 374
JO - IET Nanobiotechnology
JF - IET Nanobiotechnology
IS - 6
ER -
