In vitro generation of platelets through direct conversion: First report in My Knowledge (iMK)

Shigeo Masuda; Mo Li; Juan Carlos Izpisua Belmonte

doi:10.1038/cr.2012.142

In vitro generation of platelets through direct conversion: First report in My Knowledge (iMK)

Shigeo Masuda, Mo Li, Juan Carlos Izpisua Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.

Original language	English (US)
Pages (from-to)	176-178
Number of pages	3
Journal	Cell research
Volume	23
Issue number	2
DOIs	https://doi.org/10.1038/cr.2012.142
State	Published - Feb 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/cr.2012.142

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abstract = "Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.",

author = "Shigeo Masuda and Mo Li and Belmonte, {Juan Carlos Izpisua}",

year = "2013",

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AB - Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.

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In vitro generation of platelets through direct conversion: First report in My Knowledge (iMK)

Abstract

ASJC Scopus subject areas

UN SDGs

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