Abstract
The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2484-2487 |
| Number of pages | 4 |
| Journal | ChemMedChem |
| Volume | 13 |
| Issue number | 23 |
| DOIs | |
| State | Published - Nov 1 2018 |
| Externally published | Yes |
Bibliographical note
KAUST Repository Item: Exported on 2022-06-09Acknowledged KAUST grant number(s): OSR-2015-CCF-1974-03
Acknowledgements: This work was supported in part by the Department of Biological Sciences, University of Limerick, Limerick, Ireland. We thank King Saud University (Distinguished Scientist Fellowship Program) and King Abdullah University of Science and Technology (Award No. OSR-2015-CCF-1974-03) for their support.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
ASJC Scopus subject areas
- Organic Chemistry
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)