In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake

Olga Gladkovskaya; Yuri K. Gun'Ko; Gerard M. O'Connor; Vladimir Gogvadze; Yury Rochev

doi:10.2217/nnm-2016-0068

In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake

Olga Gladkovskaya, Yuri K. Gun'Ko, Gerard M. O'Connor, Vladimir Gogvadze, Yury Rochev

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Rapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models. In our review we aim to describe the interplay of various cell death mechanisms triggered by quantum dots as a consequence of particle parameters and experimental conditions.

Original language	English (US)
Pages (from-to)	2603-2615
Number of pages	13
Journal	Nanomedicine
Volume	11
Issue number	19
DOIs	https://doi.org/10.2217/nnm-2016-0068
State	Published - Sep 13 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was conducted under the framework of INSPIRE, the Irish Government's Programme for Research in Third Level Institutions Cycle 5, National Development Plan 2007-2013 with the assistance of the European Regional Development Fund, the Science Foundation Ireland (SFI 12/IA/1300 project) and the Ministry of Education and Science of the Russian Federation (grant no. 14.B25.31.0002) and the Russian Science Foundation, grant no. 15-15-00132. The part of this review 'ROS formation' and 'Apoptosis' was supported by the Russian Science Foundation (grant no. 14-15-00463 to V Gogvadze). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict viiith the subject matter or materials discussed in the manuscript apart from those disclosed.

Access to Document

10.2217/nnm-2016-0068

Cite this

@article{ce4ee7dbb9034d358f7fe01514777949,

title = "In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake",

abstract = "Rapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models. In our review we aim to describe the interplay of various cell death mechanisms triggered by quantum dots as a consequence of particle parameters and experimental conditions.",

author = "Olga Gladkovskaya and Gun'Ko, {Yuri K.} and O'Connor, {Gerard M.} and Vladimir Gogvadze and Yury Rochev",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was conducted under the framework of INSPIRE, the Irish Government's Programme for Research in Third Level Institutions Cycle 5, National Development Plan 2007-2013 with the assistance of the European Regional Development Fund, the Science Foundation Ireland (SFI 12/IA/1300 project) and the Ministry of Education and Science of the Russian Federation (grant no. 14.B25.31.0002) and the Russian Science Foundation, grant no. 15-15-00132. The part of this review 'ROS formation' and 'Apoptosis' was supported by the Russian Science Foundation (grant no. 14-15-00463 to V Gogvadze). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict viiith the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2016",

month = sep,

day = "13",

doi = "10.2217/nnm-2016-0068",

language = "English (US)",

volume = "11",

pages = "2603--2615",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Taylor and Francis Ltd.",

number = "19",

}

TY - JOUR

T1 - In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake

AU - Gladkovskaya, Olga

AU - Gun'Ko, Yuri K.

AU - O'Connor, Gerard M.

AU - Gogvadze, Vladimir

AU - Rochev, Yury

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was conducted under the framework of INSPIRE, the Irish Government's Programme for Research in Third Level Institutions Cycle 5, National Development Plan 2007-2013 with the assistance of the European Regional Development Fund, the Science Foundation Ireland (SFI 12/IA/1300 project) and the Ministry of Education and Science of the Russian Federation (grant no. 14.B25.31.0002) and the Russian Science Foundation, grant no. 15-15-00132. The part of this review 'ROS formation' and 'Apoptosis' was supported by the Russian Science Foundation (grant no. 14-15-00463 to V Gogvadze). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict viiith the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2016/9/13

Y1 - 2016/9/13

N2 - Rapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models. In our review we aim to describe the interplay of various cell death mechanisms triggered by quantum dots as a consequence of particle parameters and experimental conditions.

AB - Rapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models. In our review we aim to describe the interplay of various cell death mechanisms triggered by quantum dots as a consequence of particle parameters and experimental conditions.

UR - http://hdl.handle.net/10754/622560

UR - https://www.futuremedicine.com/doi/10.2217/nnm-2016-0068

UR - http://www.scopus.com/inward/record.url?scp=84990216805&partnerID=8YFLogxK

U2 - 10.2217/nnm-2016-0068

DO - 10.2217/nnm-2016-0068

M3 - Article

C2 - 27618947

SN - 1743-5889

VL - 11

SP - 2603

EP - 2615

JO - Nanomedicine

JF - Nanomedicine

IS - 19

ER -

In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this