Improving your target-template alignment with MODalign.

Alessandro Barbato, Pascal Benkert, Torsten Schwede, Anna Tramontano, Jan Kosinski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


SUMMARY: MODalign is an interactive web-based tool aimed at helping protein structure modelers to inspect and manually modify the alignment between the sequences of a target protein and of its template(s). It interactively computes, displays and, upon modification of the target-template alignment, updates the multiple sequence alignments of the two protein families, their conservation score, secondary structure and solvent accessibility values, and local quality scores of the implied three-dimensional model(s). Although it has been designed to simplify the target-template alignment step in modeling, it is suitable for all cases where a sequence alignment needs to be inspected in the context of other biological information. AVAILABILITY AND IMPLEMENTATION: Freely available on the web at Website implemented in HTML and JavaScript with all major browsers supported. CONTACT:
Original languageEnglish (US)
Pages (from-to)1038-1039
Number of pages2
Issue number7
StatePublished - Feb 4 2012
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-I1-012-43
Acknowledgements: KAUST Award No. KUK-I1-012-43 made by King Abdullah University of Science and Technology (KAUST), Fondazione Roma, the Italian Ministry of Health, Contract No. onc_ord 25/07, FIRB PROTEOMICA, and European Molecular Biology Organization (EMBO) long-term fellowship to J.K.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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