Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications

Hubert Marek Piwonski; Wei Li; Yang Wang; Tsuyoshi Michinobu; Satoshi Habuchi

doi:10.1021/acsapm.9b00967

Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications

Hubert Marek Piwonski, Wei Li, Yang Wang, Tsuyoshi Michinobu, Satoshi Habuchi

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Development of near-infrared (NIR) and shortwave infrared (SWIR) emitting fluorophores is central to the fluorescence-based bioimaging. While conjugated polymer nanoparticles (polymer dots) are one of the promising fluorophores for this application, obtaining polymer dots that show bright fluorescence, especially in the SWIR wavelength region, has been challenging. Here, we report a generalized approach to obtain bright polymer dots through a systematic characterization of photophysical properties of NIR and SWIR emitting polymer dots. Detailed photophysical characterization of a series of polymer dots fabricated using polycarbazole- (PCz-) based conjugated polymers that adopt bent and twisted conformation reveals that the fluorescence brightness of the PCz-based polymer dots is determined by subtle balance between fluorescence quenching due to polymer chain interaction inside the particles and the twisting between the donor and acceptor moieties of the conjugated polymers inside the particles. Our results provide important insight into the rational design of highly fluorescing SWIR-emitting polymer dots.

Original language	English (US)
Journal	ACS Applied Polymer Materials
DOIs	https://doi.org/10.1021/acsapm.9b00967
State	Published - Dec 18 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST) and the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-2967-CRG5. We thank Dr. Hiroyuki Fujita (Tokyo Institute of Technology) for assistance in the polymer synthesis.

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10.1021/acsapm.9b00967

https://repository.kaust.edu.sa/bitstream/10754/661426/1/Manuscript_revised%203.pdf

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@article{1142c8656406417bae815fc48c1156ec,

title = "Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications",

abstract = "Development of near-infrared (NIR) and shortwave infrared (SWIR) emitting fluorophores is central to the fluorescence-based bioimaging. While conjugated polymer nanoparticles (polymer dots) are one of the promising fluorophores for this application, obtaining polymer dots that show bright fluorescence, especially in the SWIR wavelength region, has been challenging. Here, we report a generalized approach to obtain bright polymer dots through a systematic characterization of photophysical properties of NIR and SWIR emitting polymer dots. Detailed photophysical characterization of a series of polymer dots fabricated using polycarbazole- (PCz-) based conjugated polymers that adopt bent and twisted conformation reveals that the fluorescence brightness of the PCz-based polymer dots is determined by subtle balance between fluorescence quenching due to polymer chain interaction inside the particles and the twisting between the donor and acceptor moieties of the conjugated polymers inside the particles. Our results provide important insight into the rational design of highly fluorescing SWIR-emitting polymer dots.",

author = "Piwonski, {Hubert Marek} and Wei Li and Yang Wang and Tsuyoshi Michinobu and Satoshi Habuchi",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST) and the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-2967-CRG5. We thank Dr. Hiroyuki Fujita (Tokyo Institute of Technology) for assistance in the polymer synthesis.",

year = "2019",

month = dec,

day = "18",

doi = "10.1021/acsapm.9b00967",

language = "English (US)",

journal = "ACS Applied Polymer Materials",

issn = "2637-6105",

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T1 - Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications

AU - Piwonski, Hubert Marek

AU - Li, Wei

AU - Wang, Yang

AU - Michinobu, Tsuyoshi

AU - Habuchi, Satoshi

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST) and the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-2967-CRG5. We thank Dr. Hiroyuki Fujita (Tokyo Institute of Technology) for assistance in the polymer synthesis.

PY - 2019/12/18

Y1 - 2019/12/18

N2 - Development of near-infrared (NIR) and shortwave infrared (SWIR) emitting fluorophores is central to the fluorescence-based bioimaging. While conjugated polymer nanoparticles (polymer dots) are one of the promising fluorophores for this application, obtaining polymer dots that show bright fluorescence, especially in the SWIR wavelength region, has been challenging. Here, we report a generalized approach to obtain bright polymer dots through a systematic characterization of photophysical properties of NIR and SWIR emitting polymer dots. Detailed photophysical characterization of a series of polymer dots fabricated using polycarbazole- (PCz-) based conjugated polymers that adopt bent and twisted conformation reveals that the fluorescence brightness of the PCz-based polymer dots is determined by subtle balance between fluorescence quenching due to polymer chain interaction inside the particles and the twisting between the donor and acceptor moieties of the conjugated polymers inside the particles. Our results provide important insight into the rational design of highly fluorescing SWIR-emitting polymer dots.

AB - Development of near-infrared (NIR) and shortwave infrared (SWIR) emitting fluorophores is central to the fluorescence-based bioimaging. While conjugated polymer nanoparticles (polymer dots) are one of the promising fluorophores for this application, obtaining polymer dots that show bright fluorescence, especially in the SWIR wavelength region, has been challenging. Here, we report a generalized approach to obtain bright polymer dots through a systematic characterization of photophysical properties of NIR and SWIR emitting polymer dots. Detailed photophysical characterization of a series of polymer dots fabricated using polycarbazole- (PCz-) based conjugated polymers that adopt bent and twisted conformation reveals that the fluorescence brightness of the PCz-based polymer dots is determined by subtle balance between fluorescence quenching due to polymer chain interaction inside the particles and the twisting between the donor and acceptor moieties of the conjugated polymers inside the particles. Our results provide important insight into the rational design of highly fluorescing SWIR-emitting polymer dots.

UR - http://hdl.handle.net/10754/661426

UR - https://pubs.acs.org/doi/10.1021/acsapm.9b00967

U2 - 10.1021/acsapm.9b00967

DO - 10.1021/acsapm.9b00967

M3 - Article

SN - 2637-6105

JO - ACS Applied Polymer Materials

JF - ACS Applied Polymer Materials

ER -

Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications

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