Implantable 3D Printed Drug Delivery System

Khalil Moussi; Abdullah BuKhamsin; Jürgen Kosel

doi:10.1109/TRANSDUCERS.2019.8808496

Implantable 3D Printed Drug Delivery System

Khalil Moussi, Abdullah BuKhamsin, Jürgen Kosel

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

A miniaturized drug delivery system suitable for in-vivo biomedical applications is presented. The system consists of an electrolytic pump driving a micro bellows membrane as an actuator for delivery through microneedles. A two-photon polymerization 3D printing technique was used to fabricate a reservoir equipped with microneedles. Analytical characterization of the flow rate through the microneedles showed an outgoing flow rate ranging from 63 μL/min to 520 μL/min for an applied pressure of 0.1 to 1 kPa. The assembled system with an overall size of 3.9 mm × 2.1 mm × 2 mm achieved delivery of 4 ± 0.5 μL within 12 seconds of actuation. A penetration test of the microneedle into a skin-like material confirms its potential for transdermal delivery.

Original language	English (US)
Title of host publication	2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)
Publisher	IEEE
Pages	2243-2246
Number of pages	4
ISBN (Print)	9781538681046
DOIs	https://doi.org/10.1109/TRANSDUCERS.2019.8808496
State	Published - Aug 22 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was funded and supported by King Abdullah University of Science and Technology (KAUST).

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10.1109/TRANSDUCERS.2019.8808496

https://repository.kaust.edu.sa/bitstream/10754/658662/1/IMPLANTABLE%203D%20PRINTED%20DRUG%20DELIVERY%20SYSTEM.pdf

Cite this

@inproceedings{e3273c535115470fa4a92dba1b87eca5,

title = "Implantable 3D Printed Drug Delivery System",

abstract = "A miniaturized drug delivery system suitable for in-vivo biomedical applications is presented. The system consists of an electrolytic pump driving a micro bellows membrane as an actuator for delivery through microneedles. A two-photon polymerization 3D printing technique was used to fabricate a reservoir equipped with microneedles. Analytical characterization of the flow rate through the microneedles showed an outgoing flow rate ranging from 63 μL/min to 520 μL/min for an applied pressure of 0.1 to 1 kPa. The assembled system with an overall size of 3.9 mm × 2.1 mm × 2 mm achieved delivery of 4 ± 0.5 μL within 12 seconds of actuation. A penetration test of the microneedle into a skin-like material confirms its potential for transdermal delivery.",

author = "Khalil Moussi and Abdullah BuKhamsin and J{\"u}rgen Kosel",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was funded and supported by King Abdullah University of Science and Technology (KAUST).",

year = "2019",

month = aug,

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doi = "10.1109/TRANSDUCERS.2019.8808496",

language = "English (US)",

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publisher = "IEEE",

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T1 - Implantable 3D Printed Drug Delivery System

AU - Moussi, Khalil

AU - BuKhamsin, Abdullah

AU - Kosel, Jürgen

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was funded and supported by King Abdullah University of Science and Technology (KAUST).

PY - 2019/8/22

Y1 - 2019/8/22

N2 - A miniaturized drug delivery system suitable for in-vivo biomedical applications is presented. The system consists of an electrolytic pump driving a micro bellows membrane as an actuator for delivery through microneedles. A two-photon polymerization 3D printing technique was used to fabricate a reservoir equipped with microneedles. Analytical characterization of the flow rate through the microneedles showed an outgoing flow rate ranging from 63 μL/min to 520 μL/min for an applied pressure of 0.1 to 1 kPa. The assembled system with an overall size of 3.9 mm × 2.1 mm × 2 mm achieved delivery of 4 ± 0.5 μL within 12 seconds of actuation. A penetration test of the microneedle into a skin-like material confirms its potential for transdermal delivery.

AB - A miniaturized drug delivery system suitable for in-vivo biomedical applications is presented. The system consists of an electrolytic pump driving a micro bellows membrane as an actuator for delivery through microneedles. A two-photon polymerization 3D printing technique was used to fabricate a reservoir equipped with microneedles. Analytical characterization of the flow rate through the microneedles showed an outgoing flow rate ranging from 63 μL/min to 520 μL/min for an applied pressure of 0.1 to 1 kPa. The assembled system with an overall size of 3.9 mm × 2.1 mm × 2 mm achieved delivery of 4 ± 0.5 μL within 12 seconds of actuation. A penetration test of the microneedle into a skin-like material confirms its potential for transdermal delivery.

UR - http://hdl.handle.net/10754/658662

UR - https://ieeexplore.ieee.org/document/8808496/

UR - http://www.scopus.com/inward/record.url?scp=85071906578&partnerID=8YFLogxK

U2 - 10.1109/TRANSDUCERS.2019.8808496

DO - 10.1109/TRANSDUCERS.2019.8808496

M3 - Conference contribution

SN - 9781538681046

SP - 2243

EP - 2246

BT - 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

PB - IEEE

ER -

Implantable 3D Printed Drug Delivery System

Abstract

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