Impact of MCT1 haploinsufficiency on the mouse retina

Neal S. Peachey; Minzhong Yu; John Y.S. Han; Sylvain Lengacher; Pierre J. Magistretti; Luc Pellerin; Nancy J. Philp

doi:10.1007/978-3-319-75402-4_46

Impact of MCT1 haploinsufficiency on the mouse retina

Neal S. Peachey^*, Minzhong Yu, John Y.S. Han, Sylvain Lengacher, Pierre J. Magistretti, Luc Pellerin, Nancy J. Philp

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 ^+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1 ^+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer New York LLC
Pages	375-380
Number of pages	6
DOIs	https://doi.org/10.1007/978-3-319-75402-4_46
State	Published - 2018

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1074
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Bibliographical note

Publisher Copyright:
© 2018, Springer International Publishing AG, part of Springer Nature.

Keywords

Electroretinogram
Lactate
MCT1
Retina
Transgenic mice

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-319-75402-4_46

Cite this

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abstract = " The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 +/− heterozygotes, which express half of the normal complement of MCT1. The MCT1 +/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.",

keywords = "Electroretinogram, Lactate, MCT1, Retina, Transgenic mice",

author = "Peachey, {Neal S.} and Minzhong Yu and Han, {John Y.S.} and Sylvain Lengacher and Magistretti, {Pierre J.} and Luc Pellerin and Philp, {Nancy J.}",

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AU - Peachey, Neal S.

AU - Yu, Minzhong

AU - Han, John Y.S.

AU - Lengacher, Sylvain

AU - Magistretti, Pierre J.

AU - Pellerin, Luc

AU - Philp, Nancy J.

PY - 2018

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AB - The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 +/− heterozygotes, which express half of the normal complement of MCT1. The MCT1 +/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

KW - Electroretinogram

KW - Lactate

KW - MCT1

KW - Retina

KW - Transgenic mice

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M3 - Chapter

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BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -

Impact of MCT1 haploinsufficiency on the mouse retina

Abstract

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Bibliographical note

Keywords

ASJC Scopus subject areas

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