Immunohistochemical distribution of pro-somatostatin-related peptides in cerebral cortex

John H. Morrison*, Robert Benoit, Pierre Magistretti, Floyd E. Bloom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

171 Scopus citations


Mammalian brain contains 3 peptides related to the pro-somatostatin molecule: somatostatin-14 (SS14), the form originally identified from hypothalamic extracts, somatostatin 28 (SS28) and somatostaton 28 (1-12) (SS28 (1-12)). By using antibodies which selectively recognize one or more of these 3 somatostatin-related peptides, we have characterized their immunohistochemical distribution in neocortex. These somatostatin-related peptides have a specific laminar distribution in cortex and are differentially distributed such that SS28 is largely restricted to cell bodies, whereas SS28 (1-12) is preferentially localized in neuroal processes and terminals in a density which far exceeds that revealed by SS-14 immunoreactivity. These data suggest that there may be an intraneuronal transformation from a SS28-like peptide to a SS28 (1-12)-like peptide. In addition, the enriched distribution of nerve fibers containing the antigenic determinant, SS28 (1-12), strongly implies that somatostatin-related peptides constitute a major neurotransmitter system in neocortex. The morphological characteristics of this system are homologous with long projection pathways such as the cortico-cortical specific intrinsic systems as well as projections.

Original languageEnglish (US)
Pages (from-to)344-351
Number of pages8
JournalBrain Research
Issue number2
StatePublished - Mar 7 1983


  • cerebral cortex
  • immunohistochemistry
  • peptides
  • pro-somatostatin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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