Identification and characterization of Mlr1,2: Two mouse homologues of Mblk-1, a transcription factor from the honeybee brain

Takekazu Kunieda; Jung Min Park; Hideaki Takeuchi; Takeo Kubo; Takashi Gojobori

doi:10.1016/S0014-5793(02)03858-9

Identification and characterization of Mlr1,2: Two mouse homologues of Mblk-1, a transcription factor from the honeybee brain

Takekazu Kunieda, Jung Min Park, Hideaki Takeuchi, Takeo Kubo^*, Takashi Gojobori

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We previously identified the Mblk-1 gene in the honeybee brain, which encodes a transcription factor containing two DNA binding motifs, termed RHF1 and 2 (Takeuchi et al. (2001) Insect Mol. Biol. 121, 134-140). Here, we identified two mouse Mblk1 homologues, Mlr1 and Mlr2. Both encode proteins containing a single DNA-binding motif highly conserved with RHF2 and activate transcription mediated by a DNA element recognized by honeybee Mblk-1. Mlr1 was expressed predominantly in the spermatocytes of the testis, while Mlr2 was expressed in various tissues other than testis. Mlr1 transcripts were lost in the testis of W/W^v mutant mice, suggesting a role in spermatogenesis.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	FEBS Letters
Volume	535
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(02)03858-9
State	Published - Jan 30 2003
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a Grant-in-Aid from the Bio-oriented Technology Research Advancement Institution (BRAIN).

Keywords

Brain
E93
Honeybee
Spermatocytes
Spermatogenesis
Transcription factor

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(02)03858-9

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title = "Identification and characterization of Mlr1,2: Two mouse homologues of Mblk-1, a transcription factor from the honeybee brain",

abstract = "We previously identified the Mblk-1 gene in the honeybee brain, which encodes a transcription factor containing two DNA binding motifs, termed RHF1 and 2 (Takeuchi et al. (2001) Insect Mol. Biol. 121, 134-140). Here, we identified two mouse Mblk1 homologues, Mlr1 and Mlr2. Both encode proteins containing a single DNA-binding motif highly conserved with RHF2 and activate transcription mediated by a DNA element recognized by honeybee Mblk-1. Mlr1 was expressed predominantly in the spermatocytes of the testis, while Mlr2 was expressed in various tissues other than testis. Mlr1 transcripts were lost in the testis of W/Wv mutant mice, suggesting a role in spermatogenesis.",

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author = "Takekazu Kunieda and Park, {Jung Min} and Hideaki Takeuchi and Takeo Kubo and Takashi Gojobori",

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AU - Kunieda, Takekazu

AU - Park, Jung Min

AU - Takeuchi, Hideaki

AU - Kubo, Takeo

AU - Gojobori, Takashi

N1 - Funding Information: This work was supported by a Grant-in-Aid from the Bio-oriented Technology Research Advancement Institution (BRAIN).

PY - 2003/1/30

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N2 - We previously identified the Mblk-1 gene in the honeybee brain, which encodes a transcription factor containing two DNA binding motifs, termed RHF1 and 2 (Takeuchi et al. (2001) Insect Mol. Biol. 121, 134-140). Here, we identified two mouse Mblk1 homologues, Mlr1 and Mlr2. Both encode proteins containing a single DNA-binding motif highly conserved with RHF2 and activate transcription mediated by a DNA element recognized by honeybee Mblk-1. Mlr1 was expressed predominantly in the spermatocytes of the testis, while Mlr2 was expressed in various tissues other than testis. Mlr1 transcripts were lost in the testis of W/Wv mutant mice, suggesting a role in spermatogenesis.

AB - We previously identified the Mblk-1 gene in the honeybee brain, which encodes a transcription factor containing two DNA binding motifs, termed RHF1 and 2 (Takeuchi et al. (2001) Insect Mol. Biol. 121, 134-140). Here, we identified two mouse Mblk1 homologues, Mlr1 and Mlr2. Both encode proteins containing a single DNA-binding motif highly conserved with RHF2 and activate transcription mediated by a DNA element recognized by honeybee Mblk-1. Mlr1 was expressed predominantly in the spermatocytes of the testis, while Mlr2 was expressed in various tissues other than testis. Mlr1 transcripts were lost in the testis of W/Wv mutant mice, suggesting a role in spermatogenesis.

KW - Brain

KW - E93

KW - Honeybee

KW - Spermatocytes

KW - Spermatogenesis

KW - Transcription factor

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Identification and characterization of Mlr1,2: Two mouse homologues of Mblk-1, a transcription factor from the honeybee brain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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