I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process

Liangzhen Hu, Muhammad Ijaz Hussain, Qingfu Deng, Qing Liu, Yangyang Feng, Xiaohui Zhang, Yan Xiong

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

One-step base promoted strategy for cyanation of α,α-diaryl alcohols has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, respectively, up to 99% yield. Moreover, various azides and ethers could also be accessed from their respective nucleophiles under standard reaction conditions.
Original languageEnglish (US)
Pages (from-to)308-314
Number of pages7
JournalTetrahedron
Volume75
Issue number2
DOIs
StatePublished - Jan 11 2019
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-22

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