Hyperquadrics for shape analysis of 3D nanoscale reconstructions of brain cell nuclear envelopes

M. Agus, C. Calì, A. Tapia Morales, H. O. Lehväslaiho, P. J. Magistretti, E. Gobbetti, M. Hadwiger

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Shape analysis of cell nuclei is becoming increasingly important in biology and medicine. Recent results have identified that the significant variability in shape and size of nuclei has an important impact on many biological processes. Current analysis techniques involve automatic methods for detection and segmentation of histology and microscopy images, and are mostly performed in 2D. Methods for 3D shape analysis, made possible by emerging acquisition methods capable to provide nanometric-scale 3D reconstructions, are, however, still at an early stage, and often assume a simple spherical shape. We introduce here a framework for analyzing 3D nanoscale reconstructions of nuclei of brain cells (mostly neurons), obtained by semiautomatic segmentation of electron micrographs. Our method considers an implicit parametric representation customizing the hyperquadrics formulation of convex shapes. Point clouds of nuclear envelopes, extracted from image data, are fitted to our parametrized model, which is then used for performing statistical analysis and shape comparisons. We report on the preliminary analysis of a collection of 92 nuclei of brain cells obtained from a sample of the somatosensory cortex of a juvenile rat.

Original languageEnglish (US)
Title of host publicationItalian Chapter Conference 2018 - Smart Tools and Apps in Computer Graphics, STAG 2018
EditorsAlberto Signoroni, Marco Livesu, Marco Agus
PublisherEurographics Association
Pages115-122
Number of pages8
ISBN (Electronic)9783038680758
DOIs
StatePublished - 2018
Event2018 Italian Chapter Conference - Smart Tools and Apps in Computer Graphics, STAG 2018 - Brescia, Italy
Duration: Oct 18 2018Oct 19 2018

Publication series

NameItalian Chapter Conference 2018 - Smart Tools and Apps in Computer Graphics, STAG 2018

Conference

Conference2018 Italian Chapter Conference - Smart Tools and Apps in Computer Graphics, STAG 2018
Country/TerritoryItaly
CityBrescia
Period10/18/1810/19/18

Bibliographical note

Funding Information:
Acknowledgments. This work was supported by the CRG grant no.2313 from King Abdullah University of Science and Technology KAUST-EPFL Alliance for Integrative Modeling of Brain Energy Metabolism. We also acknowledge the contribution of Sardinian Regional Authorities under project VIGEC.

Publisher Copyright:
© 2018 The Eurographics Association.

ASJC Scopus subject areas

  • Computer Science Applications
  • Computer Graphics and Computer-Aided Design

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