Hyperbranched Macromolecules Via a Novel Double-Stage Convergent Growth Approach

Karen L. Wooley, Craig J. Hawker, Jean Frechet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

380 Scopus citations


A novel double-stage convergent growth approach for the preparation of dendritic macromolecules is described. in the first stage, convergent growth with 4,4-bis(4′-hydroxyphenyl)pentanol as the building block is used to create symmetrical dendritic structures containing a large number of phenolic “surface” functionalities. in the second stage of growth, these polyphenols dendritic macromolecules are utilized as cores for the attachment of other dendritic macromolecules, derived from 3,5-dihydroxybenzyl alcohol, that contain a single benzylic bromide reactive group at their focal point. This two-stage process affords hyperbranched spherical macromolecules consisting of a flexible inner core surrounded by a more rigid outer layer. the double-stage convergent growth approach allows for the preparation of larger dendrimers in less time and with greater ease than the single-stage approach while retaining the advantages of near monodispersity and ease of purification and characterization.

Original languageEnglish (US)
Pages (from-to)4252-4261
Number of pages10
JournalJournal of the American Chemical Society
Issue number11
StatePublished - May 1 1991

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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