Hygroscopic study of glucose, citric acid, and sorbitol using an electrodynamic balance: Comparison with UNIFAC predictions

Changgeng Peng, Chak K. Chan, Albert H.L. Chow

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

The equilibrium water sorption and desorption characteristics of three pharmaceutical excipients, namely, glucose, citric acid, and sorbitol, were investigated at 25°C using an electrodynamic balance (EDB). The mass fraction of solute (mfs), defined as the ratio of the dry solute mass to the solution mass, of the additives was measured as a function of relative humidity (RH) at equilibrium. Bulk measurements and literature data suggest that these three additives all crystallize at their respective saturation conditions. However, crystallization or deliquescence was not observed for the suspended particles of the three additives. They behave as nondeliquescent materials and sorb and desorb water reversibly. At RH = 5%, citric acid particles still contain ∼8 wt% residual water, which corresponds to a stoichiometry of citric acid monohydrate. Glucose and sorbitol particles are essentially water-free. Universal Functional Activity Coefficient (UNIFAC) model predicts the water activities of glucose, citric acid, and sorbitol (expressed as mfs of the particles) to within ±16%, 24%, and 6% of those determined by the EDB, respectively. © 2001 American Association for Aerosol Research.
Original languageEnglish (US)
Pages (from-to)753-758
Number of pages6
JournalAerosol Science and Technology
Volume35
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-07-06

ASJC Scopus subject areas

  • Environmental Chemistry
  • General Materials Science
  • Pollution

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