Hydrophilization of Porous Polystyrene-Based Continuous Rod Column

Q. Ching Wang, Frantisek Svec, Jean M.J. Fréchet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Reactive porous rods of poly[(chloromethyl)styrene-codivinylbenzene] have been prepared for the first time by copolymerization of the monomers in the presence of a porogenic diluent A two-step modification process involving reaction with ethyienediamine followed%reaction with γ-gluconolactone leads to a porous medium that has highly hydrophilic surface functionalities. Preliminary chromatographic evaluation with both small molecules such as alkylbenzenes in reversed-phase mode and large proteins in hydrophobic adsorption and ion-exchange modes demonstrates that the surface of the modified rods possesses a hydrophilicity that is comparable to that of the best hydrophilic HPLC packings.

Original languageEnglish (US)
Pages (from-to)670-674
Number of pages5
Issue number3
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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