Hydrophilic, protein-resistant surface modification of polymer monoliths via photografting for multifunctional microfluidic devices

Timothy B. Stachowiak; Frantisek Svec; Jean M.J. Fréchet

Hydrophilic, protein-resistant surface modification of polymer monoliths via photografting for multifunctional microfluidic devices

Timothy B. Stachowiak, Frantisek Svec, Jean M.J. Fréchet

Research output: Contribution to conference › Paper › peer-review

Abstract

Polymer monoliths that resist the adsorption of proteins were prepared using both single- and two-step photografting of hydrophilic monomers. The adsorption of protein was measured using a fluorescent assay based on bovine serum albumin labeled with fluorescein. By photografting hydrophilic monomers such as poly(ethylene glycol) methacrylate onto polymer monoliths, protein adsorption was reduced by 98% relative to unmodified surfaces.

Original language	English (US)
Pages	227-229
Number of pages	3
State	Published - 2006
Externally published	Yes
Event	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: Nov 5 2006 → Nov 9 2006

Other

Other	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
Country/Territory	Japan
City	Tokyo
Period	11/5/06 → 11/9/06

Keywords

Adsorption
Photografting
Polymer monolith
Surface modification

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

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title = "Hydrophilic, protein-resistant surface modification of polymer monoliths via photografting for multifunctional microfluidic devices",

abstract = "Polymer monoliths that resist the adsorption of proteins were prepared using both single- and two-step photografting of hydrophilic monomers. The adsorption of protein was measured using a fluorescent assay based on bovine serum albumin labeled with fluorescein. By photografting hydrophilic monomers such as poly(ethylene glycol) methacrylate onto polymer monoliths, protein adsorption was reduced by 98% relative to unmodified surfaces.",

keywords = "Adsorption, Photografting, Polymer monolith, Surface modification",

author = "Stachowiak, {Timothy B.} and Frantisek Svec and Fr{\'e}chet, {Jean M.J.}",

year = "2006",

language = "English (US)",

pages = "227--229",

note = "10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 ; Conference date: 05-11-2006 Through 09-11-2006",

}

Hydrophilic, protein-resistant surface modification of polymer monoliths via photografting for multifunctional microfluidic devices. / Stachowiak, Timothy B.; Svec, Frantisek; Fréchet, Jean M.J.
2006. 227-229 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Hydrophilic, protein-resistant surface modification of polymer monoliths via photografting for multifunctional microfluidic devices

AU - Stachowiak, Timothy B.

AU - Svec, Frantisek

AU - Fréchet, Jean M.J.

PY - 2006

Y1 - 2006

N2 - Polymer monoliths that resist the adsorption of proteins were prepared using both single- and two-step photografting of hydrophilic monomers. The adsorption of protein was measured using a fluorescent assay based on bovine serum albumin labeled with fluorescein. By photografting hydrophilic monomers such as poly(ethylene glycol) methacrylate onto polymer monoliths, protein adsorption was reduced by 98% relative to unmodified surfaces.

AB - Polymer monoliths that resist the adsorption of proteins were prepared using both single- and two-step photografting of hydrophilic monomers. The adsorption of protein was measured using a fluorescent assay based on bovine serum albumin labeled with fluorescein. By photografting hydrophilic monomers such as poly(ethylene glycol) methacrylate onto polymer monoliths, protein adsorption was reduced by 98% relative to unmodified surfaces.

KW - Adsorption

KW - Photografting

KW - Polymer monolith

KW - Surface modification

UR - http://www.scopus.com/inward/record.url?scp=84902519968&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:84902519968

SP - 227

EP - 229

T2 - 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

Y2 - 5 November 2006 through 9 November 2006

ER -

Hydrophilic, protein-resistant surface modification of polymer monoliths via photografting for multifunctional microfluidic devices

Abstract

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Keywords

ASJC Scopus subject areas

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