Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex

Viktoriia Zubar; Jannik C. Borghs; Magnus Rueping

doi:10.1021/acs.orglett.0c01273

Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex

Viktoriia Zubar, Jannik C. Borghs, Magnus Rueping

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Abstract

A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism

Original language	English (US)
Journal	Organic Letters
DOIs	https://doi.org/10.1021/acs.orglett.0c01273
State	Published - May 4 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (FCC/1/1974).

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10.1021/acs.orglett.0c01273

https://repository.kaust.edu.sa/bitstream/10754/662745/1/Hydrogenation.pdf

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title = "Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex",

abstract = "A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism",

author = "Viktoriia Zubar and Borghs, {Jannik C.} and Magnus Rueping",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (FCC/1/1974).",

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doi = "10.1021/acs.orglett.0c01273",

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T1 - Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex

AU - Zubar, Viktoriia

AU - Borghs, Jannik C.

AU - Rueping, Magnus

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (FCC/1/1974).

PY - 2020/5/4

Y1 - 2020/5/4

N2 - A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism

AB - A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism

UR - http://hdl.handle.net/10754/662745

UR - https://pubs.acs.org/doi/10.1021/acs.orglett.0c01273

UR - http://www.scopus.com/inward/record.url?scp=85084683278&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.0c01273

DO - 10.1021/acs.orglett.0c01273

M3 - Article

C2 - 32364749

SN - 1523-7060

JO - Organic Letters

JF - Organic Letters

ER -

Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex

Abstract

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