Abstract
Nickel-catalyzed ipso-borylations and silylations of aldehydes are described for the first time. The new functional-group interconversion protocol is characterized by its scalability, functional-group tolerance and wide substrate scope, including examples of late-stage functionalization of complex molecules. The key for the successful reaction outcome is the use of a ketone as a hydride acceptor that intercepts the nickel hydride to undergo a reductive pathway, thus allowing formation of the desired C−B and C−Si bonds.
Original language | English (US) |
---|---|
Pages (from-to) | 423-427 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 26 |
Issue number | 2 |
DOIs | |
State | Published - Dec 9 2019 |
Bibliographical note
KAUST Repository Item: Exported on 2020-10-01Acknowledgements: This research was supported by King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research under award number URF/1/3030-01.