Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents

Antoni Bayes-Genis*, Carolina Soler-Botija, Jordi Farré, Pilar Sepúlveda, Angel Raya, Santiago Roura, Cristina Prat-Vidal, Carolina Gálvez-Montón, José Anastasio Montero, Dirk Büscher, Juan Carlos Izpisúa Belmonte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Myocardial infarction caused by vascular occlusion results in the formation of nonfunctional fibrous tissue. Cumulative evidence indicates that cell therapy modestly improves cardiac function; thus, novel cell sources with the potential to repair injured tissue are actively sought. Here, we identify and characterize a cell population of cardiac adipose tissue-derived progenitor cells (ATDPCs) from biopsies of human adult cardiac adipose tissue. Cardiac ATDPCs express a mesenchymal stem cell-like marker profile (strongly positive for CD105, CD44, CD166, CD29 and CD90) and have immunosuppressive capacity. Moreover, cardiac ATDPCs have an inherent cardiac-like phenotype and were able to express de novo myocardial and endothelial markers in vitro but not to differentiate into adipocytes. In addition, when cardiac ATDPCs were transplanted into injured myocardium in mouse and rat models of myocardial infarction, the engrafted cells expressed cardiac (troponin I, sarcomeric α-actinin) and endothelial (CD31) markers, vascularization increased, and infarct size was reduced in mice and rats. Moreover, significant differences between control and cell-treated groups were found in fractional shortening and ejection fraction, and the anterior wall remained significantly thicker 30. days after cardiac delivery of ATDPCs. Finally, cardiac ATDPCs secreted proangiogenic factors under in vitro hypoxic conditions, suggesting a paracrine effect to promote local vascularization. Our results indicate that the population of progenitor cells isolated from human cardiac adipose tissue (cardiac ATDPCs) may be valid candidates for future use in cell therapy to regenerate injured myocardium.

Original languageEnglish (US)
Pages (from-to)771-780
Number of pages10
JournalJournal of Molecular and Cellular Cardiology
Issue number5
StatePublished - Nov 2010

Bibliographical note

Funding Information:
This work was supported by grants from Ministerio de Educación y Ciencia ( SAF 2004-08044-C03-01 and SAF 2008-05144-C02-01 ), Secretaría de Estado de Universidades e Investigación del Ministerio de Educación y Ciencia-Programa Fulbright ( 2005-FU-27-04-05 ), and Universitat Autònoma de Barcelona ( EME2004-06 ). We also appreciate support from Fundació Daniel Bravo Andreu. Work in the laboratory of J.C.I.B. was supported by grants from CIBER , TERCEL , Fundación Cellex , MICINN, and the G. Harold and Leila Y. Mathers Charitable Foundation .


  • Cardiac adipose tissue
  • Cell transplantation
  • Myocardial infarction
  • Progenitor cells

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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