Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy

Fei Yi; Guang Hui Liu; Juan Carlos Izpisua Belmonte

doi:10.1007/s13238-012-2918-4

Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy

Fei Yi, Guang Hui Liu^*, Juan Carlos Izpisua Belmonte

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

Original language	English (US)
Pages (from-to)	246-250
Number of pages	5
Journal	Protein and Cell
Volume	3
Issue number	4
DOIs	https://doi.org/10.1007/s13238-012-2918-4
State	Published - Apr 2012
Externally published	Yes

Keywords

cell therapy
disease modeling
drug development
hepatocytes
induced pluripotent stem cells

ASJC Scopus subject areas

Biotechnology
Biochemistry
Drug Discovery
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13238-012-2918-4

Cite this

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title = "Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy",

abstract = "Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.",

keywords = "cell therapy, disease modeling, drug development, hepatocytes, induced pluripotent stem cells",

author = "Fei Yi and Liu, {Guang Hui} and Belmonte, {Juan Carlos Izpisua}",

year = "2012",

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doi = "10.1007/s13238-012-2918-4",

language = "English (US)",

volume = "3",

pages = "246--250",

journal = "Protein and Cell",

issn = "1674-800X",

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}

TY - JOUR

T1 - Human induced pluripotent stem cells derived hepatocytes

T2 - Rising promise for disease modeling, drug development and cell therapy

AU - Yi, Fei

AU - Liu, Guang Hui

AU - Belmonte, Juan Carlos Izpisua

PY - 2012/4

Y1 - 2012/4

N2 - Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

AB - Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

KW - cell therapy

KW - disease modeling

KW - drug development

KW - hepatocytes

KW - induced pluripotent stem cells

UR - http://www.scopus.com/inward/record.url?scp=84862849950&partnerID=8YFLogxK

U2 - 10.1007/s13238-012-2918-4

DO - 10.1007/s13238-012-2918-4

M3 - Review article

C2 - 22441839

AN - SCOPUS:84862849950

SN - 1674-800X

VL - 3

SP - 246

EP - 250

JO - Protein and Cell

JF - Protein and Cell

IS - 4

ER -

Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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