Host-directed editing of the SARS-CoV-2 genome.

Tobias Mourier; Mukhtar Sadykov; Michael J Carr; Gabriel Gonzalez; William W Hall; Arnab Pain

doi:10.1016/j.bbrc.2020.10.092

Host-directed editing of the SARS-CoV-2 genome.

Tobias Mourier, Mukhtar Sadykov, Michael J Carr, Gabriel Gonzalez, William W Hall, Arnab Pain

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Abstract

The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.

Original language	English (US)
Journal	Biochemical and biophysical research communications
DOIs	https://doi.org/10.1016/j.bbrc.2020.10.092
State	Published - Nov 25 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-12-02
Acknowledged KAUST grant number(s): BAS/1/1020-01-01
Acknowledgements: We thank all laboratories which have contributed sequences to the GISAID database.
This work was supported by funding from King Abdullah University of Science and Technology (KAUST), Office of Sponsored Research (OSR). Work in AP’s laboratory is supported by the KAUST faculty baseline fund (BAS/1/1020-01-01) and the R3T initiative of KAUST.

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10.1016/j.bbrc.2020.10.092

https://repository.kaust.edu.sa/bitstream/10754/666152/1/host%20directed.pdf

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title = "Host-directed editing of the SARS-CoV-2 genome.",

abstract = "The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.",

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AU - Pain, Arnab

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AB - The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.

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UR - https://linkinghub.elsevier.com/retrieve/pii/S0006291X20320210

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ER -

Host-directed editing of the SARS-CoV-2 genome.

Abstract

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