Host-directed editing of the SARS-CoV-2 genome.

Tobias Mourier, Mukhtar Sadykov, Michael J Carr, Gabriel Gonzalez, William W Hall, Arnab Pain

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
Original languageEnglish (US)
JournalBiochemical and biophysical research communications
StatePublished - Nov 25 2020

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