Hologenome analysis of two marine sponges with different microbiomes

Tae Woo Ryu, Loqmane Seridi, Lucas Moitinho-Silva, Matthew Oates, Yi Jin Liew, Charalampos Harris Mavromatis, Xiaolei Wang, Annika Haywood, Feras Fawzi Lafi, Marija Kupresanin, Rachid Sougrat, Majed A. Alzahrani, Emily Giles, Yanal Ghosheh, Celia Marei Schunter, Sebastian Baumgarten, Michael L. Berumen, Xin Gao, Manuel Aranda, Sylvain ForetJulian Gough, Christian R. Voolstra, Ute Hentschel, Timothy Ravasi

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background Sponges (Porifera) harbor distinct microbial consortia within their mesohyl interior. We herein analysed the hologenomes of Stylissa carteri and Xestospongia testudinaria, which notably differ in their microbiome content. Results Our analysis revealed that S. carteri has an expanded repertoire of immunological domains, specifically Scavenger Receptor Cysteine-Rich (SRCR)-like domains, compared to X. testudinaria. On the microbial side, metatranscriptome analyses revealed an overrepresentation of potential symbiosis-related domains in X. testudinaria. Conclusions Our findings provide genomic insights into the molecular mechanisms underlying host-symbiont coevolution and may serve as a roadmap for future hologenome analyses.
Original languageEnglish (US)
JournalBMC Genomics
Volume17
Issue number1
DOIs
StatePublished - Feb 29 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the King Abdullah University of Science and Technology. LMS was supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wuerzburg. We thank the KAUST Core Lab for performing the sequencing and assisting with the genome-size analysis. We acknowledge Till Rothig (KAUST) for contributing to the sponge sample collection, Christine Gernert (University of Wurzburg) for assisting with the TEM analysis, and Sebastian Fraune (University of Kiel) for reading the manuscript critically. We also thank several anonymous reviewers for constructive comments.

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