TY - JOUR
T1 - HIV-1-induced AIDS in monkeys
AU - Hatziioannou, Theodora
AU - Del Prete, Gregory Q.
AU - Keele, Brandon F.
AU - Estes, Jacob D.
AU - McNatt, Matthew W.
AU - Bitzegeio, Julia
AU - Raymond, Alice
AU - Rodriguez, Anthony
AU - Schmidt, Fabian
AU - Mac Trubey, C.
AU - Smedley, Jeremy
AU - Piatak, Michael
AU - KewalRamani, Vineet N.
AU - Lifson, Jeffrey D.
AU - Bieniasz, Paul D.
N1 - Generated from Scopus record by KAUST IRTS on 2023-02-15
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection.
AB - Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection.
UR - https://www.science.org/doi/10.1126/science.1250761
UR - http://www.scopus.com/inward/record.url?scp=84902664262&partnerID=8YFLogxK
U2 - 10.1126/science.1250761
DO - 10.1126/science.1250761
M3 - Article
SN - 1095-9203
VL - 344
SP - 1401
EP - 1405
JO - Science
JF - Science
IS - 6190
ER -
